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T-helper cell type 1

Known as: Th1 Cell, Type 1 T-helper cell, Cell, Th1 
Type 1 Helper Cells are a subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (3)

CD4 Positive T LymphocytesHelper-Inducer T-LymphocyteT-Lymphocyte
CD8-Positive T-LymphocytesHematopoietic and Lymphoid TissueHepatitis A Virus Cellular Receptor 2IL27RA protein, human

Papers overview

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Highly Cited
2008
Highly Cited
2008
Histamine H4 receptors modulate dendritic cell migration through skin – immunomodulatory role of histamine
Background:  Dendritic cells (DC) are the major antigen‐presenting cells and play a key role in adaptive immunity as they are… 
Highly Cited
1999
Highly Cited
1999
CD 8 a 1 and CD 8 a 2 Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo
Cells of the dendritic family display some unique properties that confer to them the capacity to sensitize naive T cells in vitro… 
Highly Cited
1999
Highly Cited
1999
Expression and kinetics of cytokines determined by intracellular staining using flow cytometry.
Highly Cited
1995
Highly Cited
1995
Regulation of immunity to malaria: valuable lessons learned from murine models.
Highly Cited
1995
Highly Cited
1995
Sequential production of Th1 and Th2 cytokines in response to live bacillus Calmette-Guérin.
Causes of individual variation in susceptibility to mycobacterial diseases are only partly understood. An efficient cell-mediated… 
Review
1995
Review
1995
The role of the innate immune response in Th1 cell development following Leishmania major infection
Infection of mice with the protozoan parasite Leishmania major is an established model with which to study the in vivo… 
Review
1991
Review
1991
A potential role for microbial superantigens in the pathogenesis of systemic autoimmune disease.
We have attempted herein to demonstrate how microbial superantigens could promote an abnormal form of "cognate" T helper-B cell… 
Highly Cited
1985
Highly Cited
1985
Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations.
Two monoclonal antibodies (HB-10 and HB-11), which react with human T, B, and NK cells, identify approximately 50% of the Leu-3… 
Highly Cited
1985
Highly Cited
1985
Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self
This study characterizes the T helper (Th) cells that initiate primary cytotoxic T lymphocyte (CTL) responses against allogeneic… 
Highly Cited
1982
Highly Cited
1982
Murine Peyer's patch T cell clones. Characterization of antigen- specific helper T cells for immunoglobulin A responses
We successfully cloned antigen-specific T cells from murine gut- associated lymphoreticular tissue, i.e., Peyer's patches, which… 
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