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Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival.
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
Molecular mapping of CD28 costimulation showed that Treg cell generation requires a motif that binds the tyrosine kinase Lck, precisely the same motif that is required for CD28costimulation of interleukin 2 production.
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice
Recent advances in the understanding of the cellular and molecular events involved in lineage-fate decision are summarized and discussed in the context of the major models of CD4/CD8-lineage choice.
Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells.
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
A homeostatic mechanism is identified that transcriptionally tailors CD8 coreceptor expression in individual CD8+ T cells to the self-specificity of their clonotypic T cell receptor (TCR), promoting the engagement of self ligands, yet avoiding autoreactivity.
Association of the Adaptor Molecule Lat with Cd4 and Cd8 Coreceptors Identifies a New Coreceptor Function in T Cell Receptor Signal Transduction
- R. Bosselut, Weiguo Zhang, J. M. Ashe, J. Kopacz, L. Samelson, A. Singer
- BiologyThe Journal of experimental medicine
- 15 November 1999
A new function for CD4 and CD8 coreceptors in TCR signal transduction is pointed to, namely to promote LAT phosphorylation by ZAP-70 by recruiting LAT to major histocompatibility complex–engaged TCR complexes.
Clonal deletion and the fate of autoreactive thymocytes that survive negative selection
This study identifies costimulation by CD28 as the intrathymic signal required for clonal deletion and identifies CD8αα+ IELs as the developmental fate of autoreactive thymocytes that survive negative selection.
Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28
- J. Punt, B. Osborne, Y. Takahama, S. Sharrow, A. Singer
- Biology, MedicineThe Journal of experimental medicine
- 1 February 1994
It is demonstrated that TCR engagement does not efficiently induce apoptosis of CD4+CD8+ thymocytes, although it generates signals that increase expression of CD5, a thymocyte differentiation marker.
Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction.
This review focuses on the phenotype, specificity, and function of the T cells mediating rejection responses against skin allografts, and on the immune mechanisms by which host T cells are either activated or rendered non-responsive by cellular populations within the graft.
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.
The results of this study demonstrate the importance of intracellular localization for CTLA-4 protein function and reveal that CTLA -4 protein externalization imparts suppressor function to both regulatory and conventional CD4(+) T cells.