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Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response.
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The mucosal immune system: from fundamental concepts to vaccine development.
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Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.
TLDR
Results show that CT acts as a mucosal adjuvant to enhance Th2-type responses and in particular, the IL-4 produced results in a characteristic Ab isotype pattern associated with this cytokine.
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Difference in susceptibility to gram-negative urinary tract infection between C3H/HeJ and C3H/HeN mice
TLDR
The relative bacterial recovery from either mouse strain was related to the overall virulence of the infecting bacterial strain, but the difference between C3H/HeJ and C3h/HeN mice was associated with responsiveness to parts of lipopolysaccharide common to the bacterial strains tested.
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Alternate Mucosal Immune System: Organized Peyer’s Patches Are Not Required for IgA Responses in the Gastrointestinal Tract1
TLDR
Results show that the MLN plays a more important role than had been appreciated until now for the induction of both mucosal and systemic Ab responses after oral immunization.
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Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues
TLDR
The results show that oral immunization with TT and the mucosal adjuvant CT selectively induced antigen-specific Th2-type responses which may represent the major helper cell phenotype involved in mucosal IgA responses in the GI tract.
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Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.
TLDR
The results are consistent with the suggestion that Ag-specific Th1 cells and their derived cytokines, IFN-gamma and IL-2, and Th2-derived IL-10 together with IL-6 produced by macrophages provide important signals for the development of mucosal IgA and serum IgG subclass responses in the absence of preferential expression of Th2 cytokines IL-4 andIL-5.
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Molecular mechanisms of immunoglobulin A defense.
TLDR
Article de synthese: Aspects generaux du systeme immun des muqueuses de l'infection par le virus HIV-1 and des potentialites of l'immunite au niveau desmuqueuses.
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A bactericidal effect for human lactoferrin.
TLDR
Streptococcus mutans and Vibrio cholerae, but not Escherichia coli, were killed by incubation with purified human apolact oferrin, contingent upon the metal-chelating properties of the lactoferrin molecule.
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Mechanisms for induction of acquired host immunity by neutrophil peptide defensins.
TLDR
These studies show that defensins enhance systemic IgG, but not IgA, Ab responses through help provided by CD4(+) Th1- and Th2-type cytokines and foster B and T cell interactions to link innate immunity with the adaptive immune system.
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