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Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response.
The mucosal immune system: from fundamental concepts to vaccine development.
Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.
Results show that CT acts as a mucosal adjuvant to enhance Th2-type responses and in particular, the IL-4 produced results in a characteristic Ab isotype pattern associated with this cytokine.
Difference in susceptibility to gram-negative urinary tract infection between C3H/HeJ and C3H/HeN mice
- L. Hagberg, R. Hull, S. Hull, J. Mcghee, S. Michalek, C. Svanborg Edén
- BiologyInfection and immunity
- 1 December 1984
The relative bacterial recovery from either mouse strain was related to the overall virulence of the infecting bacterial strain, but the difference between C3H/HeJ and C3h/HeN mice was associated with responsiveness to parts of lipopolysaccharide common to the bacterial strains tested.
Alternate Mucosal Immune System: Organized Peyer’s Patches Are Not Required for IgA Responses in the Gastrointestinal Tract1
Results show that the MLN plays a more important role than had been appreciated until now for the induction of both mucosal and systemic Ab responses after oral immunization.
Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues
- J. XU‐AMANO, H. Kiyono, J. Mcghee
- Biology, MedicineThe Journal of experimental medicine
- 1 October 1993
The results show that oral immunization with TT and the mucosal adjuvant CT selectively induced antigen-specific Th2-type responses which may represent the major helper cell phenotype involved in mucosal IgA responses in the GI tract.
Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.
The results are consistent with the suggestion that Ag-specific Th1 cells and their derived cytokines, IFN-gamma and IL-2, and Th2-derived IL-10 together with IL-6 produced by macrophages provide important signals for the development of mucosal IgA and serum IgG subclass responses in the absence of preferential expression of Th2 cytokines IL-4 andIL-5.
Molecular mechanisms of immunoglobulin A defense.
Article de synthese: Aspects generaux du systeme immun des muqueuses de l'infection par le virus HIV-1 and des potentialites of l'immunite au niveau desmuqueuses.
A bactericidal effect for human lactoferrin.
Streptococcus mutans and Vibrio cholerae, but not Escherichia coli, were killed by incubation with purified human apolact oferrin, contingent upon the metal-chelating properties of the lactoferrin molecule.
Mechanisms for induction of acquired host immunity by neutrophil peptide defensins.
- J. Lillard, P. Boyaka, O. Chertov, J. Oppenheim, J. Mcghee
- Biology, MedicineProceedings of the National Academy of Sciences…
- 19 January 1999
These studies show that defensins enhance systemic IgG, but not IgA, Ab responses through help provided by CD4(+) Th1- and Th2-type cytokines and foster B and T cell interactions to link innate immunity with the adaptive immune system.