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An improvement in overall survival among patients with metastatic melanoma has been an elusive goal. In this phase 3… Expand Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a common p40 subunit shared with IL-12. IL… Expand Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes… Expand A long-standing paradox in cellular immunology concerns the conditional requirement for CD4+ T-helper (TH) cells in the priming… Expand This report shows that cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) plays a key role in T cell–mediated dominant… Expand Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary immune responses. DCs capture and… Expand It is now clear that functionally specialized regulatory T (Treg) cells exist as part of the normal immune repertoire, preventing… Expand Apoptosis of mature T lymphocytes preserves peripheral homeostasis and tolerance by countering the profound changes in the number… Expand I thank Drs. D. V. Goeddel and P. Golstein for helpful comments on the manuscript. I am grateful to all members of my laboratory… Expand We have utilized a transendothelial lymphocyte chemotaxis assay to identify and purify a lymphocyte chemoattractant in… Expand