FAQ

Cytotoxic T-Lymphocytes

Known as: Killer T cell, Cytotoxic T lymphocyte, Cell Mediated Lympholytic Cells 
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed… (More)

Topic mentions per year

Topic mentions per year

1962-2018
0500100019622018

Related topics

Related topics

50 relations
Agonistic Anti-OX40 Monoclonal Antibody MEDI6383Anti-CD19/CD28/CD3zeta CAR Gammaretroviral Vector-transduced Autologous T Lymphocytes KTE-C19Anti-GRP78 Monoclonal Antibody PAT-SM6Anti-OX40 Monoclonal Antibody MOXR0916
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Broader (2)

CD8-Positive T-LymphocytesT-Lymphocyte

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Cytotoxic T-Lymphocytes
T-Lymphocyte
Lymphoid Tissue
Microbiological
incomplete Freund's adjuvant
sipuleucel-T

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer.
Interleukin-10 (IL-10) is known to be a tolerogenic cytokine since it inhibits pro-inflammatory cytokine production and T cell… (More)
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Highly Cited
2003
Highly Cited
2003
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes.
A long-standing paradox in cellular immunology concerns the conditional requirement for CD4+ T-helper (T(H)) cells in the priming… (More)
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Highly Cited
2003
Highly Cited
2003
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma.
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule (expressed on activated T cells and… (More)
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Highly Cited
2000
Highly Cited
2000
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
This report shows that cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a key role in T cell-mediated dominant… (More)
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Highly Cited
1998
Highly Cited
1998
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions.
Although in vivo priming of CD8+ cytotoxic T lymphocytes (CTLs) generally requires the participation of CD4+ T-helper lymphocytes… (More)
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Highly Cited
1998
Highly Cited
1998
Help for cytotoxic-T-cell responses is mediated by CD40 signalling.
Cytotoxic T lymphocytes (CTLs) which carry the CD8 antigen recognize antigens that are presented on target cells by the class I… (More)
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Highly Cited
1998
Highly Cited
1998
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.
Cytotoxic T lymphocytes (CTLs) lyse virally infected cells that display viral peptide epitopes in association with major… (More)
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Highly Cited
1997
Highly Cited
1997
Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
The precise role played by HIV-specific cytotoxic T lymphocytes (CTL) in HIV infection remains controversial. Despite strong CTL… (More)
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Highly Cited
1996
Highly Cited
1996
Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes.
It is widely believed that viral clearance is mediated principally by the destruction of infected cells by CTLs. In this report… (More)
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Highly Cited
1994
Highly Cited
1994
Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection.
Human immunodeficiency virus type 1 (HIV-1) Env-, Gag-, Pol-, Nef-, and Tat-specific cytotoxic T-lymphocyte (CTL) activities were… (More)
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