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Cytotoxic T-Lymphocytes

Known as: Killer T cell, Cytotoxic T lymphocyte, Cell Mediated Lympholytic Cells 
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed… 
National Institutes of Health

Related topics

Related topics

50 relations
2G-1 TCR Retroviral Vector-Transduced LymphocytesActivated Marrow Infiltrating LymphocytesAd5-survivin-transduced Autologous Dendritic Cell VaccineAgonistic Anti-OX40 Monoclonal Antibody MEDI6383

Papers overview

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Highly Cited
2000
Highly Cited
2000
Cd40-Independent Pathways of T Cell Help for Priming of Cd8+ Cytotoxic T Lymphocytes
In many cases, induction of CD8+ CTL responses requires CD4+ T cell help. Recently, it has been shown that a dominant pathway of… 
Highly Cited
1998
Highly Cited
1998
Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge.
Mucosal tissues are major sites of HIV entry and initial infection. Thus, the induction of a mucosal cytotoxic T lymphocyte (CTL… 
Highly Cited
1989
Highly Cited
1989
Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection.
Cytolytic T-lymphocyte (CTL) clones against an autologous melanoma (SK-MEL-29) were generated by mixed lymphocyte tumor culture… 
Highly Cited
1987
Highly Cited
1987
Cytotoxic T lymphocytes against a soluble protein
Thymus-derived (T) lymphocytes recognize antigen in conjunction with surface glycoproteins encoded by major histocompatibility… 
Highly Cited
1987
Highly Cited
1987
Cytotoxic T lymphocyte mediated lysis without release of serine esterase
Cloned cytotoxic T lymphocytes (CTL) can lyse target cells in a Ca2+-dependent or Ca2+-independent fashion, depending on the… 
Review
1987
Review
1987
LFA-1 and other accessory molecules functioning in adhesions of T and B lymphocytes.
Highly Cited
1982
Highly Cited
1982
Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens
A recently described HLA gene, SB, which maps between GLO and HLA-DR, codes for Ia-like molecules that are similar to but… 
Review
1982
Review
1982
Clonal Heterogeneity in the Functional Requirement for Lyt‐2/3 Molecules on Cytolytic T Lymphocytes (CTL): Possible Implications for the Affinity of CTL Antigen Receptors
Despite extensive investigation over the past decade, the mechanism of target cell lysis by cytolytic T lymphocytes (CTL) remains… 
Highly Cited
1981
Highly Cited
1981
Activation of human T lymphocyte subsets: helper and suppressor/cytotoxic T cells recognize and respond to distinct histocompatibility antigens.
This study was directed at determining the major histocompatibility complex (MHC) antigens recognized by helper (Leu-3) and… 
Highly Cited
1974
Highly Cited
1974
GENERATION OF CYTOTOXIC T LYMPHOCYTES IN VITRO
Mouse cytotoxic T lymphocytes (CTL) were generated in unidirectional mixed leukocyte cultures (MLC) using normal C57BL/6 spleen… 
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