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Cytotoxic T-Lymphocytes

Known as: Killer T cell, Cytotoxic T lymphocyte, Cell Mediated Lympholytic Cells 
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed… 
National Institutes of Health

Related topics

Related topics

50 relations
2G-1 TCR Retroviral Vector-Transduced LymphocytesActivated Marrow Infiltrating LymphocytesAd5-survivin-transduced Autologous Dendritic Cell VaccineAgonistic Anti-OX40 Monoclonal Antibody MEDI6383

Papers overview

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Highly Cited
2003
Highly Cited
2003
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
A long-standing paradox in cellular immunology concerns the conditional requirement for CD4+ T-helper (TH) cells in the priming… 
Highly Cited
2001
Highly Cited
2001
Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic…
Therapeutic efficacy of a tumor cell–based vaccine against experimental B16 melanoma requires the disruption of either of two… 
Highly Cited
2000
Highly Cited
2000
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
This report shows that cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) plays a key role in T cell–mediated dominant… 
Highly Cited
2000
Highly Cited
2000
Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation
It is now clear that functionally specialized regulatory T (Treg) cells exist as part of the normal immune repertoire, preventing… 
Highly Cited
1998
Highly Cited
1998
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Although in vivo priming of CD8+ cytotoxic T lymphocytes (CTLs) generally requires the participation of CD4+ T-helper lymphocytes… 
Highly Cited
1998
Highly Cited
1998
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Cytotoxic T lymphocytes (CTLs) which carry the CD8 antigen recognize antigens that are presented on target cells by the class I… 
Highly Cited
1998
Highly Cited
1998
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
Cytotoxic T lymphocytes (CTLs) lyse virally infected cells that display viral peptide epitopes in association with major… 
Highly Cited
1997
Highly Cited
1997
Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
The precise role played by HIV-specific cytotoxic T lymphocytes (CTL) in HIV infection remains controversial. Despite strong CTL… 
Highly Cited
1997
Highly Cited
1997
Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
The HIV-1-specific cytotoxic T lymphocyte (CTL) response is temporally associated with the decline in viremia during primary HIV… 
Highly Cited
1996
Highly Cited
1996
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Identification and characterization of antigen-specific T lymphocytes during the course of an immune response is tedious and… 
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