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Cytotoxic T-Lymphocytes
Known as:
Killer T cell
, Cytotoxic T lymphocyte
, Cell Mediated Lympholytic Cells
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Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed…
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National Institutes of Health
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Related topics
Related topics
50 relations
2G-1 TCR Retroviral Vector-Transduced Lymphocytes
Activated Marrow Infiltrating Lymphocytes
Ad5-survivin-transduced Autologous Dendritic Cell Vaccine
Agonistic Anti-OX40 Monoclonal Antibody MEDI6383
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
E. Janssen
,
E. Lemmens
,
T. Wolfe
,
U. Christen
,
M. Herrath
,
S. Schoenberger
Nature
2003
Corpus ID: 574770
A long-standing paradox in cellular immunology concerns the conditional requirement for CD4+ T-helper (TH) cells in the priming…
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Highly Cited
2001
Highly Cited
2001
Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic…
R. Sutmuller
,
L. V. van Duivenvoorde
,
+6 authors
C. Melief
The Journal of experimental medicine
2001
Corpus ID: 6219089
Therapeutic efficacy of a tumor cell–based vaccine against experimental B16 melanoma requires the disruption of either of two…
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Highly Cited
2000
Highly Cited
2000
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
Takeshi Takahashi
,
Tomoyuki Tagami
,
+5 authors
S. Sakaguchi
The Journal of experimental medicine
2000
Corpus ID: 8768132
This report shows that cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) plays a key role in T cell–mediated dominant…
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Highly Cited
2000
Highly Cited
2000
Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation
S. Read
,
V. Malmström
,
F. Powrie
The Journal of experimental medicine
2000
Corpus ID: 3927889
It is now clear that functionally specialized regulatory T (Treg) cells exist as part of the normal immune repertoire, preventing…
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Highly Cited
1998
Highly Cited
1998
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
S. Schoenberger
,
R. Toes
,
E. V. D. Voort
,
R. Offringa
,
C. Melief
Nature
1998
Corpus ID: 4427174
Although in vivo priming of CD8+ cytotoxic T lymphocytes (CTLs) generally requires the participation of CD4+ T-helper lymphocytes…
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Highly Cited
1998
Highly Cited
1998
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
S. R. Bennett
,
F. Carbone
,
F. Karamalis
,
R. Flavell
,
Jacques F. Miller
,
W. Heath
Nature
1998
Corpus ID: 4325396
Cytotoxic T lymphocytes (CTLs) which carry the CD8 antigen recognize antigens that are presented on target cells by the class I…
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Highly Cited
1998
Highly Cited
1998
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
K. Collins
,
Benjamin K. Chen
,
S. Kalams
,
B. Walker
,
D. Baltimore
Nature
1998
Corpus ID: 205003894
Cytotoxic T lymphocytes (CTLs) lyse virally infected cells that display viral peptide epitopes in association with major…
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Highly Cited
1997
Highly Cited
1997
Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
P. Goulder
,
R. Phillips
,
+9 authors
S. Rowland-Jones
Nature Medicine
1997
Corpus ID: 21206681
The precise role played by HIV-specific cytotoxic T lymphocytes (CTL) in HIV infection remains controversial. Despite strong CTL…
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Highly Cited
1997
Highly Cited
1997
Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
P. Borrow
,
H. Lewicki
,
+8 authors
G. Shaw
Nature Medicine
1997
Corpus ID: 8808145
The HIV-1-specific cytotoxic T lymphocyte (CTL) response is temporally associated with the decline in viremia during primary HIV…
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Highly Cited
1996
Highly Cited
1996
Phenotypic Analysis of Antigen-Specific T Lymphocytes
J. Altman
,
P. Moss
,
+5 authors
Mark M. Davis
Science
1996
Corpus ID: 12667633
Identification and characterization of antigen-specific T lymphocytes during the course of an immune response is tedious and…
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