Share This Author
Dendritic cell regulation of TH1-TH2 development
Understanding the control exerted by cytokines on T helper cell subsets 1 and 2 (TH1-TH2) development has progressed to a fairly satisfying knowledge of intracellular signals and transcription…
Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo
Evidence is obtained for maturation in vivo in response to the bacterial product lipopolysaccharide (LPS), which is interpreted to mean that LPS can cause DC in the marginal zone to mature and to migrate into and then out of the T cell areas.
CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo
- R. Maldonado-López, T. de Smedt, M. Moser
- Biology, MedicineThe Journal of experimental medicine
- 1 February 1999
It is reported here that both subclasses of DCs efficiently prime antigen-specific T cells in vivo, and direct the development of distinct T helper (Th) populations, and it is shown that interleukin 12 plays a critical role in Th1 development by CD8α+ DCs.
Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice.
- D. Bedoret, H. Wallemacq, F. Bureau
- Biology, MedicineThe Journal of clinical investigation
- 1 December 2009
A crucial role for IMs is revealed in maintaining immune homeostasis in the respiratory tract and provides an explanation for the paradox that although airborne LPS has the ability to promote the induction of Th2 responses by lung DCs, it does not provoke airway allergy under normal conditions.
Effect of interleukin‐10 on dendritic cell maturation and function
- T. de Smedt, M. van Mechelen, Geneviève De Becker, J. Urbain, O. Leo, M. Moser
- BiologyEuropean journal of immunology
- 1 May 1997
The data show that DC that have undergone maturation in vitro in the presence of IL‐10, have an impaired capacity to induce a Th1‐type response in vivo, leading to the development of Th2 lymphocytes, and suggest thatIL‐10 skews the Th1/Th2 balance to Th2 in vivo by selectively blocking IL‐12 synthesis by the antigen‐presenting cells that play a role of adjuvant of the primary immune response.
Faculty Opinions recommendation of Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.
- M. Moser
- 18 March 2014
B Lymphocytes Regulate Dendritic Cell (Dc) Function in Vivo
- V. Moulin, F. Andris, K. Thielemans, C. Maliszewski, J. Urbain, M. Moser
- BiologyThe Journal of experimental medicine
- 21 August 2000
The data suggest that B lymphocytes regulate the capacity of DCs to promote IL-4 secretion, possibly by downregulating their secretion of IL-12, thereby favoring the induction of a nonpolarized immune response.
Cytokines regulate the capacity of CD8alpha(+) and CD8alpha(-) dendritic cells to prime Th1/Th2 cells in vivo.
DC-derived IL-12 and IFN-gamma are required for Th1 priming by CD8alpha(+) DC, whereas IL-10 is required for optimal development of Th2 cells by CD9alpha(-) DC, which appears to determine the Th1/Th2 balance in vivo.
African Trypanosomiasis: Naturally Occurring Regulatory T Cells Favor Trypanotolerance by Limiting Pathology Associated with Sustained Type 1 Inflammation1
A cardinal role for naturally occurring Tregs in the development of a trypanotolerant phenotype during African trypanosomiasis is suggested, which is beneficial for the host survival by limiting the tissue damages, including liver injury.