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Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells.
Regulatory B cells control inflammation and autoimmunity in mice, including the recently identified IL-10-competent B10 cell subset that represents 1% to 3% of spleen B cells. In this study, a… Expand
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
Chronic inflammation characterized by T cell and macrophage infiltration of visceral adipose tissue (VAT) is a hallmark of obesity-associated insulin resistance and glucose intolerance. Here we show… Expand
A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses.
B cells mediate multiple functions that influence immune and inflammatory responses. In this study, T cell-mediated inflammation was exaggerated in CD19-deficient (Cd19(-/-)) mice and wild-type mice… Expand
Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression.
- T. Matsushita, K. Yanaba, J. Bouaziz, M. Fujimoto, T. Tedder
- Biology, Medicine
- The Journal of clinical investigation
- 1 October 2008
EAE is a mouse T cell-mediated autoimmune disease of the CNS used to model the human condition MS. The contributions of B cells to EAE initiation and progression are unclear. In this study, we have… Expand
CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.
Dendritic cells are potent antigen-presenting cells that initiate primary immune responses. Although dendritic cells derive from bone marrow stem cells, the intermediate stages in their development… Expand
Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice.
L-selectin, a cell adhesion molecule expressed by leukocytes, mediates the attachment of lymphocytes to high endothelial venules (HEV) of peripheral lymph nodes and mediates the earliest interactions… Expand
Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily.
Dendritic cells are potent APC that initiate primary T cell-dependent immune responses. The lack of lineage-associated cell surface Ags for human dendritic cells has made characterization of this… Expand
Regulatory B Cells Control T Cell Autoimmunity Through IL-21-Dependent Cognate Interactions
B cells regulate immune responses by producing antigen-specific antibodies. However, specific B-cell subsets can also negatively regulate T-cell immune responses, and have been termed regulatory B… Expand
B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae.
B-1a and B-1b lymphocytes were found to exhibit specialized roles in providing immunity to Streptococcus pneumoniae and differ dramatically in their developmental requirements. Transgenic mice… Expand
The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals1
- K. Yanaba, J. Bouaziz, T. Matsushita, T. Tsubata, T. Tedder
- Biology, Medicine
- The Journal of Immunology
- 15 June 2009
Autoimmunity and inflammation are controlled in part by regulatory B cells, including a recently identified IL-10-competent CD1dhighCD5+ B cell subset termed B10 cells that represents 1–3% of adult… Expand