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Hepatitis A Virus Cellular Receptor 2

Known as: CD366 Antigen, HAVCR2, T Cell Immunoglobulin Mucin 3 
An Ig domain-containing membrane receptor that is expressed by TH1 CELLS. It regulates the activation of MACROPHAGES and inhibits TH1-mediated auto… Expand
National Institutes of Health

Related topics

Related topics

15 relations
HAVCR2 geneImmune System ProcessesImmune ToleranceImmunoglobulin Domains
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.
Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T cell responses and have proven to be… Expand
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Highly Cited
2015
Highly Cited
2015
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
T-cell immunoglobulin domain and mucin domain-3 (TIM-3, also known as HAVCR2) is an activation-induced inhibitory molecule… Expand
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Review
2015
Review
2015
The evolution of checkpoint blockade as a cancer therapy: what's here, what's next?
Unleashing the immune system to fight cancer has become one of the main treatment modalities since the anti-CTLA-4 antibody… Expand
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Highly Cited
2011
Highly Cited
2011
Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.
Tumor-associated immune suppression can lead to defective T cell-mediated antitumor immunity. Here, we identified a unique… Expand
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Highly Cited
2010
Highly Cited
2010
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
Inhibitory receptors play a crucial role in regulating CD8 T-cell function during chronic viral infection. T-cell Ig- and mucin… Expand
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Highly Cited
2009
Highly Cited
2009
TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines.
TIM-3 is a molecule selectively expressed on a subset of murine IFN-gamma-secreting T helper 1 (Th1) cells but not Th2 cells, and… Expand
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Highly Cited
2008
Highly Cited
2008
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
Progressive loss of T cell functionality is a hallmark of chronic infection with human immunodeficiency virus 1 (HIV-1). We have… Expand
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Highly Cited
2007
Highly Cited
2007
Promotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune Cells
CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by numerous pathways, including the… Expand
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Highly Cited
1999
Highly Cited
1999
Two novel mucin genes down-regulated in colorectal cancer identified by differential display.
Epithelial mucins are large, secreted and cell surface glycoproteins involved in epithelial cell protection, adhesion modulation… Expand
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Highly Cited
1996
Highly Cited
1996
A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1.
Episialin (MUC1, PEM, EMA, CA15-3 antigen) is a sialylated, membrane-associated glycoprotein with an extended mucin-like… Expand
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