HAVCR2 gene

Known as: T-CELL IMMUNOGLOBULIN AND MUCIN DOMAINS-CONTAINING PROTEIN 3, HAVCR2, TIMD3 
This gene plays a role in macrophage and T helper cell activation.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2018
0102020022018

Papers overview

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Highly Cited
2013
Highly Cited
2013
T-cell immunoglobulin mucin 3 (TIM3) is an inhibitory molecule that has emerged as a key regulator of dysfunctional or exhausted… (More)
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2012
2012
Tim-3 and PD-1 are powerful immunoinhibitory molecules involved in immune tolerance, autoimmune responses, and antitumor or… (More)
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Highly Cited
2011
Highly Cited
2011
Strategies to activate and rescue exhausted tumor-specific T cells, including the use of monoclonal antibodies (mAb) that block… (More)
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2011
2011
T cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is a newly identified negative immunomodulator that is up… (More)
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Highly Cited
2011
Highly Cited
2011
Hematopoietic tissues in acute myeloid leukemia (AML) patients contain both leukemia stem cells (LSC) and residual normal… (More)
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Highly Cited
2010
Highly Cited
2010
Inhibitory receptors play a crucial role in regulating CD8 T-cell function during chronic viral infection. T-cell Ig- and mucin… (More)
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Highly Cited
2010
Highly Cited
2010
Having successfully developed mechanisms to evade immune clearance, hepatitis C virus (HCV) establishes persistent infection in… (More)
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Highly Cited
2007
Highly Cited
2007
CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by numerous pathways, including the… (More)
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Highly Cited
2006
Highly Cited
2006
T cell immunoglobulin- and mucin domain-containing molecule (TIM)3 is a T helper cell (Th)1-associated cell surface molecule that… (More)
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Highly Cited
2002
Highly Cited
2002
Activation of naive CD4(+) T-helper cells results in the development of at least two distinct effector populations, Th1 and Th2… (More)
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