Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells.

@article{Pelosi2015TargetingLT,
  title={Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells.},
  author={Elvira Pelosi and Germana Castelli},
  journal={Blood cells, molecules & diseases},
  year={2015},
  volume={55 4},
  pages={336-46}
}
Studies of xenotransplantation of bone marrow and blood cells of AML patients have supported the existence of rare leukemic stem cells, able to initiate and maintain the leukemic process and bearing the typical leukemic abnormalities. LSCs possess self-renewal capacity and are responsible for the growth of the more differentiated leukemic progeny in the bone marrow and in the blood. These cells are more resistant than bulk leukemic cells to anti-leukemic drugs, thus survive to treatment and are… CONTINUE READING