• Publications
  • Influence
Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor.
The expression/function of vascular endothelial growth factor (VEGF) receptors (VEGFR1/Flt1 and VEGFR2/KDR/Flk1) in hematopoiesis is under scrutiny. We have investigated the expression of Flt1 andExpand
  • 134
  • 7
  • Open Access
Mechanism of Enhanced Cardiac Function in Mice with Hypertrophy Induced by Overexpressed Akt*
Transgenic mice with cardiac-specific overexpression of active Akt (TG) not only exhibit hypertrophy but also show enhanced left ventricular (LV) function. In 3–4-month-old TG, heart/body weight wasExpand
  • 126
  • 7
MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis
Erythropoiesis is tightly controlled by transcription factors, one of which is the LIM domain-only protein LMO2, but little is still known of the involvement of microRNAs (miRs) in erythroid cellExpand
  • 126
  • 6
Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells
Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung cancer (15%) (SCLC).Expand
  • 66
  • 3
  • Open Access
Colorectal Cancer: Genetic Abnormalities, Tumor Progression, Tumor Heterogeneity, Clonal Evolution and Tumor-Initiating Cells
Colon cancer is the third most common cancer worldwide. Most colorectal cancer occurrences are sporadic, not related to genetic predisposition or family history; however, 20–30% of patients withExpand
  • 57
  • 3
  • Open Access
Liver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells
Liver cancer is the second most common cause of cancer-related death. The major forms of primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Both theseExpand
  • 48
  • 3
  • Open Access
A miRNA Signature in Human Cord Blood Stem and Progenitor Cells as Potential Biomarker of Specific Acute Myeloid Leukemia Subtypes
MicroRNAs (miRNAs) are important regulators of several cellular processes. During hematopoiesis, specific expression signatures have been reported in different blood cell lineages and stages ofExpand
  • 23
  • 3
Esophageal Cancer: Genomic and Molecular Characterization, Stem Cell Compartment and Clonal Evolution
Esophageal cancer (EC) is the eighth most common cancer and is the sixth leading cause of death worldwide. The incidence of histologic subtypes of EC, esophageal adenocarcinoma (EAC) and esophagealExpand
  • 28
  • 3
  • Open Access
miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development
MicroRNAs (miRNAs or miRs) are a class of evolutionarily-conserved small, regulatory non-coding RNAs, 19–3 nucleotides in length, that negatively regulate protein coding gene transcripts’ expression.Expand
  • 63
  • 2
  • Open Access
Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells.
Studies of xenotransplantation of bone marrow and blood cells of AML patients have supported the existence of rare leukemic stem cells, able to initiate and maintain the leukemic process and bearingExpand
  • 25
  • 2