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Endothelial progenitor cell biology in disease and tissue regeneration
Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia, diabetic retinopathy, and in cancer. The discovery that these cells can be mobilized from theirExpand
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Functional equivalents of interferon‐mediated signals needed for induction of an mRNA can be generated by double‐stranded RNA and growth factors.
In our earlier studies we demonstrated that in HeLaM cells, interferon‐alpha produces two functionally distinguishable signals, both of which are needed for induced transcription of mRNA 561 andExpand
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Metastatic phenotype is regulated by estrogen in thyroid cells.
BACKGROUND Over 200 million people worldwide are affected by thyroid proliferative diseases, including cancer, adenoma, and goiter, annually. The incidences of thyroid malignancies are three to fourExpand
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3,3'-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer.
Epidemiological evidences suggest that the progression and promotion of prostate cancer (CaP) can be modulated by diet. Since all men die with prostate cancer rather than of the disease, it is ofExpand
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Estrogen Induced Metastatic Modulators MMP-2 and MMP-9 Are Targets of 3,3′-Diindolylmethane in Thyroid Cancer
Background Thyroid cancer is the most common endocrine related cancer with increasing incidences during the past five years. Current treatments for thyroid cancer, such as surgery or radioactiveExpand
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Synthetic Toll Like Receptor-4 (TLR-4) Agonist Peptides as a Novel Class of Adjuvants
Background Adjuvants serve as catalysts of the innate immune response by initiating a localized site of inflammation that is mitigated by the interactions between antigens and toll like receptorExpand
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Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer.
Indole-3-carbinol (I3C), a compound present as glucobracissin in cruciferous vegetables has anticancer activities which is in line with some of the epidemiological evidence that suggests a beneficialExpand
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Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine.
Transcription of several interferon-inducible human genes is also induced by double-stranded RNA. The nature and the mechanism of action of signals generated by interferons and by double-stranded RNAExpand
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Anti-tumor effects of PC-SPES, an herbal formulation in prostate cancer.
Prostate cancer is the most common cancer amongst males in developed countries. Surgical removal of the prostate effectively cures the primary disease but the metastatic disease is refractory to mostExpand
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Selective responsiveness of human breast cancer cells to indole-3-carbinol, a chemopreventive agent.
BACKGROUND Indole-3-carbinol (I3C), a compound found in cabbage, broccoli, and brussels sprouts, inhibits the growth of mammary tumors when fed to certain strains of mice. The chemopreventive andExpand
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