• Publications
  • Influence
[Neurology of eye movements].
  • N. Shimizu
  • Medicine
  • Rinsho shinkeigaku = Clinical neurology
  • 1 December 2000
Eye movements are necessary for clear and stable vision, for which images of the world should be brought to the fovea and be held steady on the retina. The main types of eye movements consist ofExpand
  • 1,239
  • 102
Isolation of Epstein-Barr virus (EBV)-negative cell clones from the EBV-positive Burkitt's lymphoma (BL) line Akata: malignant phenotypes of BL cells are dependent on EBV.
During cultivation of the Epstein-Barr virus (EBV)-positive Burkitt's lymphoma (BL) line Akata, it was noted that EBV DNA is lost from some of the cells. Isolation of EBV-positive and EBV-negativeExpand
  • 280
  • 10
  • PDF
[Cushing's disease].
  • N. Shimizu
  • Medicine
  • Nihon rinsho. Japanese journal of clinical…
  • 1 October 1993
The following recent topics on the pathogenesis, unusual cases, treatment and the long-term prognosis of Cushing' Disease were presented and discussed. 1. hyperplasia of ACTH producing pituitaryExpand
  • 164
  • 10
A Putative G Protein-Coupled Receptor, RDC1, Is a Novel Coreceptor for Human and Simian Immunodeficiency Viruses
ABSTRACT More than 10 G protein-coupled receptors (GPCRs) have been shown to act as coreceptors for infection of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virusExpand
  • 133
  • 10
A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice.
Chronic inflammation has been postulated to play an important role in the pathogenesis of insulin resistance. Inducible nitric oxide synthase (iNOS) has been implicated in many human diseasesExpand
  • 179
  • 8
  • PDF
Malignant transformation of B lymphoma cell line BJAB by Epstein–Barr virus‐encoded small RNAs
EBV‐encoded small RNAs (EBERs) are non‐polyadenylated and abundantly transcribed RNAs, whose functions have not yet been fully elucidated. Here, we report that the EBV‐negative B lymphoma cell line,Expand
  • 74
  • 7
An Orphan G Protein-Coupled Receptor, GPR1, Acts as a Coreceptor To Allow Replication of Human Immunodeficiency Virus Types 1 and 2 in Brain-Derived Cells
ABSTRACT Twelve G protein-coupled receptors, including chemokine receptors, act as coreceptors and determinants for the cell tropisms of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simianExpand
  • 74
  • 7
Leptin regulates chondrocyte differentiation and matrix maturation during endochondral ossification.
Leptin has been suggested to mediate a variety of actions, including bone development, via its ubiquitously expressed receptor (Ob-Rb). In this study, we investigated the role of leptin inExpand
  • 99
  • 6
Nitrosative stress and pathogenesis of insulin resistance.
Insulin resistance is a major causative factor for type 2 diabetes and is associated with increased risk of cardiovascular disease. Despite intense investigation for a number of years, molecularExpand
  • 125
  • 5
Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65
S-nitrosylation of the deacetylase SIRT1 functions as a proinflammatory switch in aging and inflammatory disorders. Flipping the SIRT1 Switch During Inflammation In aging-related diseases, chronicExpand
  • 80
  • 5
  • PDF