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Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis.
The relation between microRNA expression and progression and prognosis of gastric cancer and histological subtypes showed different microRNA signatures: eight microRNAs were upregulated in diffuse-type and four in intestinal-type cancer. Expand
Forty-three cases of obturator hernia.
The use of pelvic CAT in cases of suspected obturator hernia significantly enhances preoperative diagnostic accuracy and helps to decrease both intestinal resection rate and surgical mortality. Expand
Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line.
- K. Imamura, T. Ogura, A. Kishimoto, M. Kaminishi, H. Esumi
- Medicine, Chemistry
- Biochemical and biophysical research…
- 21 September 2001
This work found cell growth to be suppressed by AICAR treatment in HepG2 because of p53 accumulation, which was associated with p53-Ser15 phosphorylation, and a motif very similar to the consensus motif of AMPK phosphorylations was found around p53 -Ser15. Expand
Current State of Gastric Stump Carcinoma in Japan: Based on the Results of a Nationwide Survey
This large series of surveys suggest that there are two distinct biological plausibilities in the development of gastric stump carcinoma: it develops in a shorter time intervals of 10 years or less since the original gastrectomy, and it develops during a longer time interval of 20 years or more, may come from gast rectomy-relating mechanisms after Gastrectomy for original benign diseases. Expand
Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer.
Although prothymosin-alpha is overexpressed in gastric adenocarcinoma, it is not associated with alterations in survival and loss of ERp57 expression correlated with more aggressive disease and could provide useful prognostic information for gastric cancer patients. Expand
Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry
Postoperative outcome of the patients with primary gastric carcinoma in Japan have apparently improved in advanced cases and among the aged population when compared with the archival data. Expand
Lysyl Oxidase Is a Tumor Suppressor Gene Inactivated by Methylation and Loss of Heterozygosity in Human Gastric Cancers
Data showed that LOX is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in gastric cancers, and possibly also in other cancers. Expand
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling
- M. Kano, Y. Bae, +12 authors K. Miyazono
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 27 February 2007
Low-dose TβR-I inhibitor altered neither TGF-β signaling in cancer cells nor the amount of fibrotic components, however, it decreased pericyte coverage of the endothelium without reducing endothelial area specifically in tumor neovasculature and promoted accumulation of macromolecules, including anticancer nanocarriers, in the tumors. Expand
Gender differences in cytokine secretion by human peripheral blood mononuclear cells: role of estrogen in modulating LPS-induced cytokine secretion in an ex vivo septic model.
A gender difference in PBMCs responsiveness to LPS and E2 stimulation and E1-modulated cytokine secretion is demonstrated, which may partially explain the mechanism underlying the poorer outcome of male sepsis patients. Expand
Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils.
This study shows that Hp eradication may be useful as a prevention approach against stomach cancer. Expand