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Five somatostatin receptors (SSTRs) bind somatostatin-14 (S-14) and somatostatin-28 (S-28), but SSTR5 has the highest affinity… Expand Somatostatin exerts diverse effects in various tissues upon binding its specific membrane receptors. Recently, we have cloned… Expand We have isolated a gene coding for a fourth human somatostatin (somatotropin release-inhibiting factor) receptor. This additional… Expand The PCR and conventional library screening were used to clone the brain-specific somatostatin receptor rSSTR-4 from a rat genomic… Expand Immunocytochemical and electrophysiological evidence suggests that somatostatin may be a transmitter in the hippocampus. To… Expand The distribution of somatostatinlike immunoreactivity was studied in the hippocampal formation, retrohippocampal region, and… Expand Mammalian brain contains 3 peptides related to the pro-somatostatin molecule: somatostatin-14 (SS14), the form originally… Expand Abstract Using an iodinated analog of a large (28 residues) and biologically active form of somatostatin, 125 I[Leu 8 ,D-Trp 22… Expand Somatostatin-28 (SS-28) is 380 times as potent as somatostatin-14 (SS-14) to inhibit acutely insulin secretion induced by… Expand We have isolated form extracts of ovine hypothalami two molecules characterized as somatostatin-28 and somatostatin-4-28… Expand