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Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
A peptide has been isolated from ovine hypothalamus which, at 1 x 10-9M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its
Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.
A 44 amino acid peptide with growth hormone-releasing activity has been isolated from a human tumor of the pancreas that had caused acromegaly and has full biological activity in vitro and in vivo specifically to stimulate the secretion of immunoreactive growth hormone.
Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.
The two major mitogenic polypeptides for endothelial cells have been purified to homogeneity and the available protein sequence data demonstrate the existence of significant structural homology between the two polyPEptides.
Immunohistochemical Localization of Novel CART Peptides in Rat Hypothalamus, Pituitary and Adrenal Gland
The findings indicate the presence of CART peptide(s) in the hypothalamus, pituitary, and adrenal gland and present evidence for the possible processing of the CART pro‐peptide into smaller peptide fragments.
Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6).
Six different insulin-like growth factor binding proteins (IGFBPs) have been identified by molecular cloning of their cDNAs from rat and human tissues and designated as IGFBP-1, -2, -3, -4, -5 and
Primary structure of PDC-109, a major protein constituent of bovine seminal plasma.
The two major protein components of bovine seminal plasma, PDC-109 and BSP I, have been purified by gel filtration, partition chromatography and reverse-phase high performance liquid chromatography
Urocortin, corticotropin releasing factor-2 receptors and energy balance.
The data suggest that the central CRF(2) receptor may primarily mediate the anorexic, but not the metabolic effects of CRF.
Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane
It is shown here that protein kinase C phosphorylates threonine 654 in the human EGF receptor, in a position to modulate signalling between this internal domain and the external EGF-binding domain.
The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion.
Support is provided for the hypothesis that GRF and SRIF are secreted tonically from the hypothalamus into the hypophyseal portal blood, and that superimposed upon this steady state release is an additional 3- to 4-h rhythmic surge of each peptide, providing for integration of the ultradian rhythm of GH secretion, as observed in peripheral blood.
Differential distribution of urocortin- and corticotropin-releasing factor-like immunoreactivities in the rat brain
Urocortin and corticotropin-releasing factor appear to have different distribution patterns which may be indicative of their respective physiological functions.