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Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF‐κB‐independent, FoxO1‐dependent mechanism
Myostatin, a transforming growth factor‐beta (TGF‐β) super‐family member, has been well characterized as a negative regulator of muscle growth and development. Myostatin has been implicated inExpand
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Conservation status of New Zealand freshwater fish, 2009
Abstract The threat status of 74 freshwater and estuarine fish present in New Zealand was determined. Fifty-one native taxa were ranked of which 67% were considered Threatened or At Risk. A singleExpand
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Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6).
Six different insulin-like growth factor binding proteins (IGFBPs) have been identified by molecular cloning of their cDNAs from rat and human tissues and designated as IGFBP-1, -2, -3, -4, -5 andExpand
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A retinoblastoma-binding protein related to a negative regulator of Ras in yeast
THE growth suppression function of the retinoblastoma protein (Rb) is thought to be mediated by Rb binding to cellular proteins1. p48 is one of the major proteins that binds to a putative functionalExpand
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The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion.
To further delineate the relationship between GH-releasing factor (GRF) and somatostatin (SRIF) in generation of the ultradian rhythm of GH secretion, we used two GRF peptides, human pancreas (hp)Expand
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Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease
IN Alzheimer's disease (AD) there are dramatic reductions in the content of corticotropin releasing factor (CRF)1–4, reciprocal increases in CRF receptors1,2, and morphological abnormalities in CRFExpand
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Molecular heterogeneity of follistatin, an activin-binding protein. Higher affinity of the carboxyl-terminal truncated forms for heparan sulfate proteoglycans on the ovarian granulosa cell.
Follistatin (FS), an activin-binding protein, is a monomer derived from two polypeptide core sequences of 315 (FS-315) and 288 (FS-288) amino acids originated from alternatively spliced mRNA. ToExpand
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A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin.
The 9-23 amino acid region of the insulin B chain (B9-23) is a dominant epitope recognized by pathogenic T lymphocytes in nonobese diabetic mice, the animal model for type 1 diabetes. We describeExpand
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Differential distribution of urocortin- and corticotropin-releasing factor-like immunoreactivities in the rat brain
Urocortin, a novel 40 amino acid neuropeptide, is a member of the corticotropin-releasing factor family. With 45% homology to corticotropin-releasing factor, urocortin binds with similar affinity toExpand
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Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein
FOLLOWING induction of experimental encephalomyelitis with a T-cell clone, L10C1, that is specific for the myelin basic protein epitope p87–99, the inflammatory infiltrate in the central nervousExpand
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