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PACAP type I receptor activation regulates ECL cells and gastric acid secretion.
- N. Zeng, C. Athmann, +5 authors J. Pisegna
- Biology, Medicine
- The Journal of clinical investigation
- 15 November 1999
PACAP effects on acid secretion were determined in fistula rats with or without neutralizing anti-somatostatin antibodies, and the presence of PAC1 but not vasoactive intestinal polypeptide (VIP) receptor (VPAC) products were absent. Expand
Gastrin, CCK, signaling, and cancer.
Recent advances in defining the role of gastrin and CCK in the control of cell proliferation innormal and cancer cells and in dissecting the signal transduction pathways that mediate the proliferative responses induced by these hormonal GI peptides in a variety of normal and cancer cell model systems are reviewed. Expand
The treatment of Helicobacter pylori infection in the management of peptic ulcer disease.
Successful eradication of H. pylori infection markedly reduces the risk of recurrent peptic ulcers and, if this therapeutic approach is taken with all patients with peptic Ulcers, the recurrence of ulcers should become a rarity in medical practice. Expand
Primary structures of PYY, [Pro(34)]PYY, and PYY-(3-36) confer different conformations and receptor selectivity.
- D. Keire, P. Mannon, M. Kobayashi, J. Walsh, T. Solomon, J. Reeve
- Chemistry, Medicine
- American journal of physiology. Gastrointestinal…
- 1 July 2000
Patterns support the hypothesis that Y(1) and Y(2) receptor subtype binding affinities depend on the secondary and tertiary solution state structures of PYY and its analogs. Expand
Gastric acid secretion rate and buffer content of the stomach after eating. Results in normal subjects and in patients with duodenal ulcer.
It was shown that the rate of acid secretion in response to a steak meal in seven duodenal ulcer patients was twice the rate achieved in six control subjects and that the amount of acid secreted after eating exceeded the peak histamine response in the ulcers but not in the controls. Expand
Direct Observation of Endocytosis of Gastrin Releasing Peptide and Its Receptor (*)
- E. Grady, L. Slice, W. Brant, J. Walsh, D. Payan, N. Bunnett
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 3 March 1995
GRP and its receptor are rapidly internalized into early endosomes and then dissociate in an acidified compartment, which indicates that GRP is probably degraded whereas the GRP-R recycles. Expand
Immunoneutralization of Somatostatin, Insulin, and Glucagon Causes Alterations in Islet Cell Secretion in the Isolated Perfused Human Pancreas
The variation in hormonal responses to immunoneutralization during stimulated and nonstimulated glucose conditions suggests that a dynamic association exists between the pancreatic cells. Expand
Regulation of gastric acid secretion.
Interference with the potentiating interactions between stimulants, anticholinergic agents and cimetidine display an apparent cross-specificity in vitro that resembles the effects of these agents in intact mucosa which may account for the interdependence of secretagogue action observed in vivo. Expand
Calcitonin gene-related peptide mediates the protective effect of sensory nerves in a model of colonic injury.
- M. Reinshagen, G. Flämig, +5 authors G. Adler
- The Journal of pharmacology and experimental…
- 1 August 1998
CGRP exerts mucosal protection during chronic experimental colitis, and treatment with the specific SP receptor antagonist did not significantly alter the severity of colitis at 7 days compared with the control group. Expand
The neuronal origin of bombesin-like immunoreactivity in the rat gastrointestinal tract
The results support the possibilities that bombesin-like peptides are neurotransmitters in the gut and that they could play a role in the modulation of gastrointestinal motility and in the release of gastrin. Expand