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Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor.
Vascular endothelial cell growth factor (VEGF), also known as vascular permeability factor, is an endothelial cell mitogen which stimulates angiogenesis. Here we report that a previously identifiedExpand
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Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.
A 44 amino acid peptide with growth hormone-releasing activity has been isolated from a human tumor of the pancreas that had caused acromegaly. The primary structure of the tumor-derived peptide isExpand
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A male accessory gland peptide that regulates reproductive behavior of female D. melanogaster
The adult male accessory glands of D. melanogaster synthesize and secrete a peptide that represses female sexual receptivity and stimulates oviposition. Normally, this peptide is transferred toExpand
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Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.
The two major mitogenic polypeptides for endothelial cells have been purified to homogeneity. The complete primary structure of bovine pituitary basic fibroblast growth factor (FGF) and theExpand
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Primary structure of PDC-109, a major protein constituent of bovine seminal plasma.
The two major protein components of bovine seminal plasma, PDC-109 and BSP I, have been purified by gel filtration, partition chromatography and reverse-phase high performance liquid chromatographyExpand
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Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo.
Tumor necrosis factor type alpha (TNF-alpha) inhibits endothelial cell proliferation in vitro. Basal cell growth (in the absence of exogenously added growth factor) and fibroblast growth factorExpand
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γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE 1
Abstract— γ‐Vinyl GABA (4‐amino‐hex‐5‐enoic acid, RMI 71754) is a catalytic inhibitor of GABA‐T in vitro. When given by a peripheral route to mice, it crosses the blood‐brain barrier and induces aExpand
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Fluorometric assay of proteins in the nanogram range.
The reagent fluorescamine has been used for the fluorometric assay of proteins based on their content of free amino groups. A manual assay is reported which is applicable to 500 ng of protein. AExpand
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Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an anti-angiogenic therapeutic strategy
Biological evidence suggests that interference with the function of the angiogenic growth factor receptor VEGFR2 (flk1/KDR) is a particularly promising strategy to inhibit tumor-induced angiogenesis.Expand
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VEGF receptor subtypes KDR and FLT1 show different sensitivities to heparin and placenta growth factor.
Vascular endothelial growth factor (VEGF) is an angiogenic growth factor which binds to two structurally related tyrosine kinase receptors denoted KDR and FLT1. To compare the interaction of VEGFExpand
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