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Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa.
NUCB2 gene expression is significantly regulated by nutritional status, suggesting a regulatory role of peripheral nesfatin-1 in energy homeostasis.
Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice.
The results indicate the existence of a functional synergistic interaction between leptin and CCK leading to early suppression of food intake which involves CCK-A receptors and capsaicin-sensitive afferent fibers.
Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor.
Data indicate that nesfatin-1 acts centrally to reduce dark phase FI through CRF(2)-receptor-dependent pathways after forebrain injection and CRF (2) receptor-independent pathways after hindbrain injection.
Cholecystokinin inhibits gastric motility and emptying via a capsaicin-sensitive vagal pathway in rats.
It is demonstrated that CCK-8 decreases gastric motility in the gastric corpus and delays gastric emptying by a capsaicin-sensitive vagal afferent pathway and these same afferent fibers may also play a physiological role in the Gastric empties of liquids.
Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists.
Evidence that members of the corticotropin releasing factor (CRF) family assume distinct structures when interacting with theCRF(1) and CRF(2) receptors is presented and deletions and substitutions known to increase duration of action are introduced to yield antagonists.
Cyclic vomiting syndrome in adults
This article is a state‐of‐knowledge overview on CVS in adults and is intended to provide a framework for management and further investigations into CVD in adults.
The bile acid TGR5 membrane receptor: from basic research to clinical application.
Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: role of CRF receptor subtypes 1 and 2.
Data show that i.p. CRF-induced opposite actions on upper and lower gut transit in conscious mice are mediated by different CRF receptor subtypes: the activation of CRF(1) receptors stimulates colonic propulsive activity, whereas activation ofCRF(2) receptors inhibits gastric emptying.
Mechanisms and treatment of postoperative ileus.
A multimodality treatment approach should include limiting the administration of agents known to contribute to postoperative ileus (narcotics), using thoracic epidurals with local anesthetics when possible, and selectively applying nasogastric decompression.