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Intercellular Calcium Signaling in Astrocytes via ATP Release through Connexin Hemichannels*
Astrocytes are capable of widespread intercellular communication via propagated increases in intracellular Ca2+ concentration. We have used patch clamp, dye flux, ATP assay, and Ca2+ imagingExpand
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Connexins regulate calcium signaling by controlling ATP release.
Forced expression of gap junction proteins, connexins, enables gap junction-deficient cell lines to propagate intercellular calcium waves. Here, we show that ATP secretion from the poorly coupledExpand
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ATP-Mediated Glia Signaling
Glia calcium signaling has recently been identified as a potent modulator of synaptic transmission. We show here that the spatial expansion of calcium waves is mediated by ATP and subsequentExpand
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Implications and challenges of connexin connections to cancer
The idea that the gap junction family of proteins, connexins, are tumour suppressors has been widely supported through numerous cancer models. However, the paradigm that connexins and enhanced gapExpand
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Amyloid β-Induced Death in Neurons Involves Glial and Neuronal Hemichannels
The mechanisms involved in Alzheimer's disease are not completely understood and how glial cells contribute to this neurodegenerative disease remains to be elucidated. Because inflammatory treatmentsExpand
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The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes
In the brain, astrocytes represent the cellular population that expresses the highest amount of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap junction channelsExpand
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Intercellular calcium signaling via gap junctions in glioma cells
Calcium signaling in C6 glioma cells in culture was examined with digital fluorescence video microscopy. C6 cells express low levels of the gap junction protein connexin43 and have correspondinglyExpand
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Specific Gap Junctions Enhance the Neuronal Vulnerability to Brain Traumatic Injury
Traumatic brain injury results in neuronal loss and associated neurological deficits. Although most research on the factors leading to trauma-induced damage focuses on synaptic or ionic mechanisms,Expand
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ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
J. Neurochem. (2011) 118, 826–840.
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CCN3 (NOV) Interacts with Connexin43 in C6 Glioma Cells
Many tumor cells exhibit aberrant gap junctional intercellular communication, which can be restored by transfection with connexin genes. We have previously discovered that overexpression ofExpand
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