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Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
A peptide has been isolated from ovine hypothalamus which, at 1 x 10-9M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. ItsExpand
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Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.
A 44 amino acid peptide with growth hormone-releasing activity has been isolated from a human tumor of the pancreas that had caused acromegaly. The primary structure of the tumor-derived peptide isExpand
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EFFECT OF THE STRESS OF INJECTIONS ON THE SERUM CONCENTRATION OF CORTISOL, PROLACTIN, AND GROWTH HORMONE IN GILTS AND LACTATING SOWS
Three experiments were conducted to determine the effect of subcutaneous injections of saline on serum concentrations of cortisol, prolactin and growth hormone in cycling gilts and lactating sows. InExpand
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Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation. Possible role of IGF-1-binding proteins.
OBJECTIVE To characterize the insulin-like growth factor 1 (IGF-1) receptor in human osteoarthritic (OA) and normal adult chondrocytes. The biologic response of chondrocytes to IGF-1 stimulation wasExpand
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Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor.
The hypophysiotropic peptide, growth hormone-releasing factor (GRF), was isolated from human hypothalamic-hypophysial tissues by means of acid extraction, immunoaffinity chromatography, gelExpand
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Selective effects of somatostatin-14, -25 and -28 on in vitro insulin and glucagon secretion
The widely occurring1–3 tetradecapeptide somatostatin (SRIF-14) has been variously implicated4–8 as a neurotransmitter, a neurohormone, a cybernin (local regulatory factor) and a hormone. In theExpand
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Immunohistochemical detection of growth hormone-releasing factor in brain
The concept of a hypothalamic neurohumoral control for anterior pituitary secretion1 postulates the existence of a growth hormone-releasing factor (GRF) of neuronal origin that stimulates theExpand
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Growth hormone-releasing factor regulates growth hormone mRNA in primary cultures of rat pituitary cells.
A peptide with high intrinsic activity for specifically stimulating the secretion of immunoreactive growth hormone (GH; somatotropin) has been characterized and reproduced by total synthesis. ThisExpand
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Antiserum to somatostatin reverses starvation-induced inhibition of growth hormone but not insulin secretion.
The role of SRIF in starvation-induced inhibition of GH and insulin secretion was assessed by passive immunization with anti-SRIF serum. Six-hour secretory profiles obtained from chronicallyExpand
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Primary structure of ovine hypothalamic somatostatin-28 and somatostatin-25.
The primary structure of the NH2-terminally extended somatostatins isolated from ovine hypothalamic extracts, one containing 28 residues and the other 25, has been determined. The structure ofExpand
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