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Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
It is demonstrated that Aβ is produced and released both in vivo and in vitro, and new opportunities for developing diagnostic tests for Alzheimer's disease and therapeutic strategies aimed at reducing the cerebral deposition of Aβ are offered.
Cleavage of amyloid beta peptide during constitutive processing of its precursor.
Direct protein structural analyses showed that constitutive processing in human embryonic kidney 293 cells cleaves APP in the interior of the A Beta P, thus preventing A beta P deposition.
Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.
- R. Guillemin, P. Brazeau, P. Böhlen, F. Esch, N. Ling, W. B. Wehrenberg
- Biology, ChemistryScience
- 5 November 1982
A 44 amino acid peptide with growth hormone-releasing activity has been isolated from a human tumor of the pancreas that had caused acromegaly and has full biological activity in vitro and in vivo specifically to stimulate the secretion of immunoreactive growth hormone.
Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein
Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.
- F. Esch, A. Baird, R. Guillemin
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 October 1985
The two major mitogenic polypeptides for endothelial cells have been purified to homogeneity and the available protein sequence data demonstrate the existence of significant structural homology between the two polyPEptides.
Primary structure of PDC-109, a major protein constituent of bovine seminal plasma.
Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin
It is proposed that the FSH-releasing substance, which is active in picomolar concentrations, is a heterodimeric protein composed of the two β-subunits of inhibins A and B linked by interchain disulphide bond(s).
Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins
Using recombinant proteins, it is shown that moesin and its close relatives ezrin and radixin can reconstitute stress fiber assembly, cortical actin polymerization and focal complex formation in response to activation of Rho and Rac.
p120, a p120-related protein (p100), and the cadherin/catenin complex
It is shown that endothelial and epithelial cells express p120 and p100, a 100-kD, p120- related protein, which suggests that p120/p100 may participate in regulating the function of cadherins and, thereby, other processes influenced by cell-cell adhesion.
Primary structure of the human follistatin precursor and its genomic organization.
- S. Shimasaki, M. Koga, R. Guillemin
- BiologyProceedings of the National Academy of Sciences…
- 1 June 1988
The structure of the complete human follistatin precursor as well as its genomic organization have been determined and the genomic organization is similar to that of the human epidermal growth factor gene and thus supports the notion of exon shuffling during evolution.