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Riluzole

Known as: 2-Amino-6-trifluoromethoxybenzothiazole, 2 Amino 6 trifluoromethoxybenzothiazole, 2-Amino-6-(trifluoromethoxy)benzothiazole 
A benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic activities. While the mechanism of action of riluzole is… 
National Institutes of Health

Related topics

Related topics

22 relations
Amyotrophic Lateral SclerosisBenzothiazolesHypersensitivityIn Blood

Broader (5)

AnestheticsAnticonvulsantsExcitatory Amino Acid AntagonistsNeuroprotective Agents

Narrower (4)

Impax Brand of RiluzolePK-26124RP-54274Rilutek

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Translating biological findings into new treatment strategies for amyotrophic lateral sclerosis (ALS)
2010
2010
Increased survival and reinnervation of cervical motoneurons by riluzole after avulsion of the C7 ventral root.
Although adult motoneurons do not die if their axons are injured at some distance from the cell body, they are unable to survive… 
2008
2008
In vitro evidence for impaired neuroprotective capacities of adult mesenchymal stem cells derived from a rat model of familial amyotrophic lateral sclerosis (hSOD1G93A)
Highly Cited
2008
Highly Cited
2008
Riluzole augmentation in treatment-refractory obsessive-compulsive disorder: a series of 13 cases, with long-term follow-up.
To the Editors:First-line treatments for obsessive-compulsive disorder (OCD)-cognitive-behavioral therapy and pharmacotherapy… 
Review
2007
Review
2007
Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation.
2005
2005
The effect of glutamate receptor blockers on glutamate release following spinal cord injury. Lack of evidence for an ongoing feedback cascade of damage → glutamate release → damage → glutamate…
Highly Cited
2004
Highly Cited
2004
Modulation of AMPA receptors in spinal motor neurons by the neuroprotective agent riluzole
We investigated the interaction of riluzole, a therapeutic agent used in amyotrophic lateral sclerosis (ALS), with α‐amino‐3… 
2001
2001
The effect of riluzole treatment in rats on the survival of injured adult and grafted embryonic motoneurons
The effect of riluzole on the survival of injured motoneurons was studied. The L4 ventral root was avulsed and reimplanted into… 
1999
1999
A Comparison of the Pharmacokinetics and Tolerability of Riluzole after Repeat Dose Administration in Healthy Elderly and Young Volunteers
The pharmacokinetics and tolerability of the novel antiexcitatory agent, riluzole, were compared in 18 healthy elderly and 18… 
Highly Cited
1998
Highly Cited
1998
Riluzole attenuates cortical lesion size, but not hippocampal neuronal loss, following traumatic brain injury in the rat
The neuroprotective effects of Riluzole, a compound with several mechanisms of action including the inhibition of sodium channel… 
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