Riluzole

Known as: 2-Amino-6-trifluoromethoxybenzothiazole, 2 Amino 6 trifluoromethoxybenzothiazole, 2-Amino-6-(trifluoromethoxy)benzothiazole 
A benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic activities. While the mechanism of action of riluzole is… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Amyotrophic lateral sclerosis (ALS) is a devastating condition with an estimated mortality of 30,000 patients a year worldwide… (More)
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Review
2017
Review
2017
BACKGROUND Traumatic spinal cord injuries (SCI) have devastating consequences for the physical, financial, and psychosocial well… (More)
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Highly Cited
2010
Highly Cited
2010
Growing evidence indicates that glia pathology and amino-acid neurotransmitter system abnormalities contribute to the… (More)
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Highly Cited
2009
Highly Cited
2009
Parkinson plus diseases, comprising mainly progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are rare… (More)
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Highly Cited
2004
Highly Cited
2004
1. Riluzole is used for the treatment of amyotrophic lateral sclerosis and reported to have neuroprotective effects in animal… (More)
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Highly Cited
2000
Highly Cited
2000
The effects of 0.1-100 microM riluzole, a neuroprotective agent with anticonvulsant properties, were studied on neurons from rat… (More)
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Highly Cited
1997
Highly Cited
1997
The effect of the glutamate antagonist riluzole on excitatory and inhibitory phenomena in the human motor system was studied by… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Amyotrophic lateral sclerosis (ALS) is a progressive disease with no effective treatment. In an initial study… (More)
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Highly Cited
1996
Highly Cited
1996
Familial amyotrophic lateral sclerosis (FALS) has been linked in some families to dominant mutations of the SOD1 gene encoding Cu… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Amyotrophic lateral sclerosis is a progressive motor neuron disease for which there is no adequate treatment. Some… (More)
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