Riluzole

Known as: 2-Amino-6-trifluoromethoxybenzothiazole, 2 Amino 6 trifluoromethoxybenzothiazole, 2-Amino-6-(trifluoromethoxy)benzothiazole 
A benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic activities. While the mechanism of action of riluzole is… (More)
National Institutes of Health

Related topics

Related topics

21 relations
Amyotrophic Lateral SclerosisBenzothiazolesHypersensitivityIn Blood
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Broader (5)

AnestheticsAnticonvulsantsExcitatory Amino Acid AntagonistsNeuroprotective Agents
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Narrower (4)

Impax Brand of RiluzolePK-26124RP-54274Rilutek

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?
Amyotrophic lateral sclerosis (ALS) is a devastating condition with an estimated mortality of 30,000 patients a year worldwide… (More)
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Review
2017
Review
2017
Traumatic Spinal Cord Injury-Repair and Regeneration.
BACKGROUND Traumatic spinal cord injuries (SCI) have devastating consequences for the physical, financial, and psychosocial well… (More)
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Highly Cited
2010
Highly Cited
2010
Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole
Growing evidence indicates that glia pathology and amino-acid neurotransmitter system abnormalities contribute to the… (More)
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Highly Cited
2009
Highly Cited
2009
Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: The NNIPPS Study
Parkinson plus diseases, comprising mainly progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are rare… (More)
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Highly Cited
2004
Highly Cited
2004
Riluzole Enhances Glutamate Uptake in Rat Astrocyte Cultures
1. Riluzole is used for the treatment of amyotrophic lateral sclerosis and reported to have neuroprotective effects in animal… (More)
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Highly Cited
2000
Highly Cited
2000
Riluzole inhibits the persistent sodium current in mammalian CNS neurons.
The effects of 0.1-100 microM riluzole, a neuroprotective agent with anticonvulsant properties, were studied on neurons from rat… (More)
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Highly Cited
1997
Highly Cited
1997
The glutamate antagonist Riluzole suppresses intracortical facilitation
The effect of the glutamate antagonist riluzole on excitatory and inhibitory phenomena in the human motor system was studied by… (More)
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Highly Cited
1996
Highly Cited
1996
Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II.
BACKGROUND Amyotrophic lateral sclerosis (ALS) is a progressive disease with no effective treatment. In an initial study… (More)
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Highly Cited
1996
Highly Cited
1996
Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis.
Familial amyotrophic lateral sclerosis (FALS) has been linked in some families to dominant mutations of the SOD1 gene encoding Cu… (More)
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Highly Cited
1994
Highly Cited
1994
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group.
BACKGROUND Amyotrophic lateral sclerosis is a progressive motor neuron disease for which there is no adequate treatment. Some… (More)
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