T. Mcintosh

Publications348
h-index95
Citations29,802
Highly Influential Citations1,102
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Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model
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Lateral fluid percussion brain injury: a 15-year review and evaluation.
TLDR
It is concluded that the LFP brain injury model is an appropriate tool to study the cellular and mechanistic aspects of human TBI that cannot be addressed in the clinical setting, as well as for the development and characterization of novel therapeutic interventions.
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Repetitive Mild Brain Trauma Accelerates Aβ Deposition, Lipid Peroxidation, and Cognitive Impairment in a Transgenic Mouse Model of Alzheimer Amyloidosis
TLDR
This is the first experimental evidence linking TBI to mechanisms of AD by showing that repetitive TBI accelerates brain Aβ accumulation and oxidative stress, which it is suggested could work synergistically to promote the onset or drive the progression of AD.
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Experimental Brain Injury Induces Regionally Distinct Apoptosis during the Acute and Delayed Post-Traumatic Period
TLDR
The data suggest that the apoptotic response to trauma is regionally distinct and may be involved in both acute and delayed patterns of cell death.
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A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects.
TLDR
The results suggest that this new model of parasagittal CCI in the mouse mimics a number of well-established sequelae observed in previously characterized brain injury models using other rodent species.
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Experimental models of traumatic brain injury: Do we really need to build a better mousetrap?
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A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats
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Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.
TLDR
Using the terminal deoxynucleotidyl transferase-mediated biotinylated deoxyuridine triphosphate nick end labeling (TUNEL) method, data suggest that apoptosis, in addition to necrotic cell death, occurs after traumatic brain injury, and that internucleosomal fragmentation of DNA may be associated with certain types of necrotIC cell death.
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Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients.
TLDR
Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury and may significantly improve the management of athletes suffering from concussion.
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The duality of the inflammatory response to traumatic brain injury
TLDR
The implications of this duality of the post-traumatic inflammatory response for the treatment of brain-injured patients using anti-inflammatory strategies are discussed.
View on Springer
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