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Lack of myostatin results in excessive muscle growth but impaired force generation
- H. Amthor, R. Macharia, +10 authors K. Patel
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 6 February 2007
The lack of myostatin promotes growth of skeletal muscle, and blockade of its activity has been proposed as a treatment for various muscle-wasting disorders. Here, we have examined two independent… Expand
Adaptation of mammalian skeletal muscle fibers to chronic electrical stimulation.
Contractile properties and susceptibility to exercise-induced damage of normal and mdx mouse tibialis anterior muscle.
1. The functional properties of tibialis anterior muscles of normal adult (C57BL/10) and age-matched dystrophin-deficient (C57BL/10 mdx) mice have been investigated in situ. Comparisons were made… Expand
Delayed riluzole treatment is able to rescue injured rat spinal motoneurons
The effect of delayed 2-amino-6-trifluoromethoxy-benzothiazole (riluzole) treatment on injured motoneurons was studied. The L4 ventral root of adult rats was avulsed and reimplanted into the spinal… Expand
Neural control of phenotypic expression in mammalian muscle fibers.
In this review, the present knowledge about the mechanisms involved in the control of the phenotypic expression of mammalian muscle fibers is summarized. There is a discussion as to how the activity… Expand
Prolonged contraction-relaxation cycle of fast-twitch muscles in parvalbumin knockout mice.
- B. Schwaller, J. Dick, +8 authors M. Celio
- Medicine, Biology
- The American journal of physiology
- 1 February 1999
The calcium-binding protein parvalbumin (PV) occurs at high concentrations in fast-contracting vertebrate muscle fibers. Its putative role in facilitating the rapid relaxation of mammalian… Expand
The effects of different patterns of muscle activity on capillary density, mechanical properties and structure of slow and fast rabbit muscles
SummaryWhen rabbit fast muscles were chronically stimulated at a frequency naturally occurring in nerves to slow muscles (10 Hz), there was a transformation towards a slow muscle type such as an… Expand
What does chronic electrical stimulation teach us about muscle plasticity?
The model of chronic low-frequency stimulation for the study of muscle plasticity was developed over 30 years ago. This protocol leads to a transformation of fast, fatigable muscles toward slower,… Expand
The influence of activity on some contractile characteristics of mammalian fast and slow muscles.
1. The time course of contraction and relaxation in the isometric twitch of a rabbit soleus muscle becomes more rapid following tenotomy and spinal cord section. This increase in speed could be… Expand
Muscle development in mdx mutant mice.
Mechanical and contractile properties of tibialis anterior (TA) muscles from X-linked muscular dystrophic (mdx) mutant mice at different stages of development are compared to those of muscles from… Expand