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- Publications
- Influence
The changing scene of amyotrophic lateral sclerosis
- W. Robberecht, T. Philips
- Medicine
- Nature Reviews Neuroscience
- 1 April 2013
Several recent breakthroughs have provided notable insights into the pathogenesis of amyotrophic lateral sclerosis (ALS), with some even shifting our thinking about this neurodegenerative disease and… Expand
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
- D. Lambrechts, E. Storkebaum, +31 authors P. Carmeliet
- Biology, Medicine
- Nature Genetics
- 2003
Amyotrophic lateral sclerosis (ALS) is an incurable degenerative disorder of motoneurons. We recently reported that reduced expression of Vegfa causes ALS-like motoneuron degeneration in Vegfaδ/δ… Expand
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
- B. Oosthuyse, L. Moons, +29 authors P. Carmeliet
- Biology, Medicine
- Nature Genetics
- 2001
Hypoxia stimulates angiogenesis through the binding of hypoxia-inducible factors to the hypoxia-response element in the vascular endothelial growth factor (Vegf) promotor. Here, we report that… Expand
The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis.
- L. Van Den Bosch, P. van Damme, E. Bogaert, W. Robberecht
- Biology, Medicine
- Biochimica et biophysica acta
- 1 November 2006
Unfortunately and despite all efforts, amyotrophic lateral sclerosis (ALS) remains an incurable neurodegenerative disorder characterized by the progressive and selective death of motor neurons. The… Expand
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
- Ana Jovičić, Jérôme Mertens, +12 authors A. Gitler
- Biology, Medicine
- Nature Neuroscience
- 1 September 2015
C9orf72 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Dipeptide repeat proteins (DPRs) produced by unconventional translation of the… Expand
Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy
- J. Irobi, K. Impe, +20 authors V. Timmerman
- Biology, Medicine
- Nature Genetics
- 1 May 2004
Distal hereditary motor neuropathies are pure motor disorders of the peripheral nervous system resulting in severe atrophy and wasting of distal limb muscles. In two pedigrees with distal hereditary… Expand
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
- E. Storkebaum, Diether Lambrechts, +18 authors P. Carmeliet
- Medicine
- Nature Neuroscience
- 2005
Neurotrophin treatment has so far failed to prolong the survival of individuals affected with amyotrophic lateral sclerosis (ALS), an incurable motoneuron degenerative disorder. Here we show that… Expand
Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
- T. Philips, W. Robberecht
- Biology, Medicine
- The Lancet Neurology
- 1 March 2011
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) are characterised by the appearance of reactive microglial and astroglial cells, a… Expand
HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease
- C. d’Ydewalle, J. Krishnan, +7 authors L. Bosch
- Biology, Medicine
- Nature Medicine
- 1 August 2011
Charcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral nervous system. Mutations in the 27-kDa small heat-shock protein gene (HSPB1) cause axonal CMT or distal… Expand
Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy
- O. Evgrafov, I. Mersiyanova, +23 authors V. Timmerman
- Biology, Medicine
- Nature Genetics
- 2 May 2004
Charcot-Marie-Tooth disease (CMT) is the most common inherited neuromuscular disease and is characterized by considerable clinical and genetic heterogeneity. We previously reported a Russian family… Expand