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The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis
Overall, while pharmacological antidepressant treatment reduced depressive symptoms, it did not reduce serum levels of TNFα, but antidepressant treatment did reduce levels of IL-1β and possibly those ofIL-6, which are consistent with the possibility that inflammatory cytokines contribute to depressive symptoms and that antidepressants block the effects ofinflammatory cytokines on the brain.
Meta-analysis of the symptom structure of obsessive-compulsive disorder.
- M. Bloch, A. Landeros-Weisenberger, M. Rosário, C. Pittenger, J. Leckman
- PsychologyThe American journal of psychiatry
- 1 December 2008
A four-factor structure explained a large proportion of the heterogeneity in the clinical symptoms of OCD and further item-level factor analyses are needed to determine the appropriate placement of miscellaneous somatic and checking OCD symptoms.
A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder
- M. Bloch, A. Landeros-Weisenberger, B. Kelmendi, V. Coric, M. Bracken, J. Leckman
- Psychology, MedicineMolecular Psychiatry
- 4 April 2006
Antipsychotic augmentation in SRI-refractory OCD is indicated in patients who have been treated for at least 3 months of maximal-tolerated therapy of an SRI, and evidence regarding the efficacy of quetiapine and olanzapine is inconclusive.
Clinical course of Tourette syndrome.
Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis.
Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment.
Systematic Review: Pharmacological and Behavioral Treatment for Trichotillomania
Tourette Syndrome: The Self Under Siege
With identification of specific genes of major effect and advances in the understanding of the neural circuitry of sensorimotor gating, habit formation, and procedural memory—together with insights from postmortem brain studies, in vivo brain imaging, and electrophysiologic recordings—the authors might be on the threshold of a deeper understand of the phenomenology and natural history of Tourette syndrome.
Clinical assessment of Tourette syndrome and tic disorders
Systematic Review of Proinflammatory Cytokines in Obsessive-Compulsive Disorder
A meta-analysis demonstrated a significant reduction in IL-1β levels in OCD and a moderating effect of comorbid depression on TNF-α levels, and possible moderating effects of age and medication use on IL-6 levels.