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Amyotrophic Lateral Sclerosis

Known as: Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Gehrig Disease, Disease, Lou-Gehrigs 
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is… 
National Institutes of Health

Related topics

Related topics

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Narrower (14)

AMYOTROPHIC LATERAL SCLEROSIS 1AMYOTROPHIC LATERAL SCLEROSIS 2, JUVENILE (disorder)AMYOTROPHIC LATERAL SCLEROSIS 3 (disorder)AMYOTROPHIC LATERAL SCLEROSIS 5
AMYOTROPHIC LATERAL SCLEROSIS 15, WITH OR WITHOUT FRONTOTEMPORAL DEMENTIAAMYOTROPHIC LATERAL SCLEROSIS 20AMYOTROPHIC LATERAL SCLEROSIS 21Amyotrophic Lateral Sclerosis With Dementia

Broader (2)

Anterior Horn Cell DiseaseMotor Neuron Disease

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Risk factors for amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. It is typically fatal within 2–5 years of symptom… 
Highly Cited
2008
Highly Cited
2008
TDP‐43 mutation in familial amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. Accumulating evidence has shown that 43kDa TAR‐DNA… 
Highly Cited
2007
Highly Cited
2007
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.
Amyotrophic lateral sclerosis (ALS) is a late-onset neurological disorder characterized by death of motoneurons. Mutations in Cu… 
Highly Cited
2006
Highly Cited
2006
ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
We recently identified angiogenin (ANG) as a candidate susceptibility gene for amyotrophic lateral sclerosis (ALS), a… 
Highly Cited
2001
Highly Cited
2001
Histological Evidence of Protein Aggregation in Mutant SOD1 Transgenic Mice and in Amyotrophic Lateral Sclerosis Neural Tissues
The mechanisms leading to neurodegeneration in ALS (amyotrophic lateral sclerosis) are not well understood, but cytosolic protein… 
Highly Cited
1999
Highly Cited
1999
Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degeneration resulting in paralysis and death, usually within 3… 
Highly Cited
1997
Highly Cited
1997
Decreased Zinc Affinity of Amyotrophic Lateral Sclerosis‐Associated Superoxide Dismutase Mutants Leads to Enhanced Catalysis of Tyrosine Nitration by Peroxynitrite
Abstract: Mutations to Cu/Zn superoxide dismutase (SOD) linked to familial amyotrophic lateral sclerosis (ALS) enhance an unknown… 
Highly Cited
1994
Highly Cited
1994
Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder primarily affecting motor neurons. The etiology of the… 
Highly Cited
1982
Highly Cited
1982
Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam.
Scanning electron microscopy with energy-dispersive x-ray spectrometry was used to analyze the elemental content of… 
Highly Cited
1981
Highly Cited
1981
A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease
The causes of amyotrophic lateral sclerosis, Parkinson disease, and Alzheimer disease are unknown. Furthermore, treatment for two… 
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