Amyotrophic Lateral Sclerosis

Known as: Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Gehrig Disease, Disease, Lou-Gehrigs 
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Amyotrophic lateral sclerosis (ALS) is a devastating condition with an estimated mortality of 30,000 patients a year worldwide… (More)
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Review
2017
Review
2017
Approximately 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD). PrLDs are low-complexity domains that… (More)
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Review
2017
Review
2017
Increasing numbers of individuals, particularly the elderly, suffer from neurodegenerative disorders. These diseases are normally… (More)
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Review
2013
Review
2013
Several recent breakthroughs have provided notable insights into the pathogenesis of amyotrophic lateral sclerosis (ALS), with… (More)
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Review
2011
Review
2011
Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease of the human motor system. In this Seminar… (More)
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Highly Cited
2010
Highly Cited
2010
Amyotrophic lateral sclerosis (ALS) has its onset in middle age and is a progressive disorder characterized by degeneration of… (More)
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Review
2009
Review
2009
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive muscular paralysis reflecting… (More)
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Highly Cited
2008
Highly Cited
2008
Recently, TDP-43 was identified as a key component of ubiquitinated aggregates in amyotrophic lateral sclerosis (ALS), an adult… (More)
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Highly Cited
2006
Highly Cited
2006
Ubiquitin-positive, tau- and alpha-synuclein-negative inclusions are hallmarks of frontotemporal lobar degeneration with… (More)
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Highly Cited
1993
Highly Cited
1993
AMYOTROPHIC lateral sclerosis (ALS) is a degenerative disorder of motor neurons in the cortex, brainstem and spinal cord1,2. Its… (More)
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