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Amyotrophic Lateral Sclerosis
Known as:
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
, Gehrig Disease
, Disease, Lou-Gehrigs
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A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is…
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National Institutes of Health
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Related topics
Related topics
48 relations
Narrower (14)
AMYOTROPHIC LATERAL SCLEROSIS 1
AMYOTROPHIC LATERAL SCLEROSIS 2, JUVENILE (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 3 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 5
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AMYOTROPHIC LATERAL SCLEROSIS 15, WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA
AMYOTROPHIC LATERAL SCLEROSIS 20
AMYOTROPHIC LATERAL SCLEROSIS 21
Amyotrophic Lateral Sclerosis With Dementia
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Broader (2)
Anterior Horn Cell Disease
Motor Neuron Disease
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Amyotrophic lateral sclerosis.
A. Ludolph
,
J. Brettschneider
,
Jochen H Weishaupt
Current Opinion in Neurology
2012
Corpus ID: 770132
PURPOSE OF REVIEW The field of amyotrophic lateral sclerosis (ALS) has seen a number of remarkable advances during recent years…
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Highly Cited
2008
Highly Cited
2008
TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
J. Sreedharan
,
I. Blair
,
+18 authors
C. Shaw
Science
2008
Corpus ID: 28744172
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder characterized pathologically by ubiquitinated TAR DNA…
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Highly Cited
2008
Highly Cited
2008
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
E. Kabashi
,
P. Valdmanis
,
+12 authors
G. Rouleau
Nature Genetics
2008
Corpus ID: 6952835
Recently, TDP-43 was identified as a key component of ubiquitinated aggregates in amyotrophic lateral sclerosis (ALS), an adult…
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Highly Cited
2006
Highly Cited
2006
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
M. Neumann
,
Deepak M. Sampathu
,
+16 authors
V. Lee
Science
2006
Corpus ID: 8620103
Ubiquitin-positive, tau- and α-synuclein–negative inclusions are hallmarks of frontotemporal lobar degeneration with ubiquitin…
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Review
2006
Review
2006
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
P. Pasinelli
,
Robert H. Brown
Nature Reviews Neuroscience
2006
Corpus ID: 1177022
Amyotrophic lateral sclerosis (ALS) is a paralytic disorder caused by motor neuron degeneration. Mutations in more than 50 human…
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Review
2000
Review
2000
El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis
B. Brooks
,
Robert G. Miller
,
M. Swash
,
T. Munsat
Amyotrophic Lateral Sclerosis and other Motor…
2000
Corpus ID: 22725949
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving primarily motor neurons in the cerebral…
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Highly Cited
1995
Highly Cited
1995
Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis
J. Rothstein
,
M. van Kammen
,
A. Levey
,
L. Martin
,
R. Kuncl
Annals of Neurology
1995
Corpus ID: 6889308
The pathogenesis of sporadic amyotrophic lateral sclerosis (ALS) is unknown, but defects in synaptosomal high‐affinity glutamate…
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Highly Cited
1994
Highly Cited
1994
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group.
G. Bensimon
,
L. Lacomblez
,
V. Meininger
New England Journal of Medicine
1994
Corpus ID: 43034414
BACKGROUND Amyotrophic lateral sclerosis is a progressive motor neuron disease for which there is no adequate treatment. Some…
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Highly Cited
1993
Highly Cited
1993
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
D. Rosen
,
T. Siddique
,
+30 authors
Robert H. Brown
Nature
1993
Corpus ID: 265436
AMYOTROPHIC lateral sclerosis (ALS) is a degenerative disorder of motor neurons in the cortex, brainstem and spinal cord1,2. Its…
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Highly Cited
1993
Highly Cited
1993
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase.
H. Deng
,
A. Hentati
,
+17 authors
T. Siddique
Science
1993
Corpus ID: 40475689
Single-site mutants in the Cu,Zn superoxide dismutase (SOD) gene (SOD1) occur in patients with the fatal neurodegenerative…
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