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A double‐blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease
Fetal nigral transplantation currently cannot be recommended as a therapy for PD based on results, and Stratification based on disease severity showed a treatment effect in milder patients.
Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two…
The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy
Preliminary neuropathological criteria were used by 7 neuropathologists to blindly evaluate 25 cases of various tauopathies, including CTE, Alzheimer’s disease, progressive supranuclear palsy, argyrophilic grain disease, corticobasal degeneration, primary age-related tauopathy, and parkinsonism dementia complex of Guam to pave the way towards future clinical and mechanistic studies.
Effects of footwear and strike type on running economy.
Minimally shodrunners are modestly but significantly more economical than traditionally shod runners regardless of strike type, after controlling for shoe mass and stride frequency.
TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy
- A. McKee, B. Gavett, A. Budson
- Biology, MedicineJournal of neuropathology and experimental…
- 1 September 2010
This work has found the first pathological evidence that repetitive head trauma experienced in collision sports might be associated with the development of a motor neuron disease.
Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene.
- W. Shu, J. Cho, J. Buxbaum
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 5 July 2005
A role for Foxp2 in cerebellar development and in a developmental process that subsumes social communication functions in diverse organisms is supported, supported by linkage studies implicating 7q31 in autism and in specific language impairment.
Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
This animal model induced by proteasome inhibitors closely recapitulates key features of PD and may be valuable in studying etiopathogenic mechanisms and putative neuroprotective therapies for the illness.
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
It is found that FTLD-TDP associates with multiple SNPs mapping to a single linkage disequilibrium block on 7p21 that contains TMEM 106B, which implicate variants in TMEM106B as a strong risk factor for FTLD, suggesting an underlying pathogenic mechanism.
Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease
Analysis of the ASM deficient mice showed their tissues had no detectable ASM activity, the blood cholesterol levels and sphingomyelin in the liver and brain were elevated, and atrophy of the cerebellum and marked deficiency of Purkinje cells was evident.