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- Publications
- Influence
A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
- A. Renton, Elisa Majounie, +73 authors B. Traynor
- Biology, Medicine
- Neuron
- 20 October 2011
The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) locus contains one of the last major unidentified autosomal-dominant genes underlying these common… Expand
Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia
- O. Butovsky, Mark P. Jedrychowski, +15 authors H. Weiner
- Medicine, Biology
- Nature Neuroscience
- 8 December 2013
Microglia are myeloid cells of the CNS that participate both in normal CNS function and in disease. We investigated the molecular signature of microglia and identified 239 genes and 8 microRNAs that… Expand
Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate
- J. Rothstein, M. Dykes-Hoberg, +8 authors D. Welty
- Chemistry, Medicine
- Neuron
- 1 March 1996
Three glutamate transporters have been identified in rat, including astroglial transporters GLAST and GLT-1 and a neuronal transporter EAAC1. Here we demonstrate that inhibition of the synthesis of… Expand
Localization of neuronal and glial glutamate transporters
- J. Rothstein, Lee Martin, A. Levey, M. Dykes-Hoberg, R. W. Kuncl
- Biology, Medicine
- Neuron
- 1 September 1994
The cellular and subcellular distributions of the glutamate transporter subtypes EAAC1, GLT-1, and GLAST in the rat CNS were demonstrated using anti-peptide antibodies that recognize the C-terminal… Expand
Oligodendroglia metabolically support axons and contribute to neurodegeneration
- Y. Lee, B. Morrison, +10 authors J. Rothstein
- Biology, Medicine
- Nature
- 14 June 2012
Oligodendroglia support axon survival and function through mechanisms independent of myelination, and their dysfunction leads to axon degeneration in several diseases. The cause of this degeneration… Expand
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
- J. Rothstein, S. Patel, +12 authors P. Fisher
- Biology, Medicine
- Nature
- 6 January 2005
Glutamate is the principal excitatory neurotransmitter in the nervous system. Inactivation of synaptic glutamate is handled by the glutamate transporter GLT1 (also known as EAAT2; refs 1, 2), the… Expand
From charcot to lou gehrig: deciphering selective motor neuron death in als
- D. Cleveland, J. Rothstein
- Biology, Medicine
- Nature Reviews Neuroscience
- 1 November 2001
Since its description by Charcot more than 130 years ago, the mechanism underlying the characteristic selective degeneration and death of motor neurons in amyotrophic lateral sclerosis has remained a… Expand
C9orf72 Nucleotide Repeat Structures Initiate Molecular Cascades of Disease
- Aaron R. Haeusler, Christopher J. Donnelly, +9 authors J. Wang
- Biology, Medicine
- Nature
- 5 March 2014
A hexanucleotide repeat expansion (HRE), (GGGGCC)n, in C9orf72 is the most common genetic cause of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia… Expand
Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis
- J. Rothstein, M. van Kammen, A. Levey, L. Martin, R. Kuncl
- Biology, Medicine
- Annals of neurology
- 1 July 1995
The pathogenesis of sporadic amyotrophic lateral sclerosis (ALS) is unknown, but defects in synaptosomal high‐affinity glutamate transport have been observed. In experimental models, chronic loss of… Expand
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
- Ke Zhang, Christopher J. Donnelly, +18 authors J. Rothstein
- Biology, Medicine
- Nature
- 3 September 2015
The hexanucleotide repeat expansion (HRE) GGGGCC (G4C2) in C9orf72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recent studies support an HRE RNA… Expand