Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Prostaglandin H2

Known as: PGH2, Prosta-5,13-dien-1-oic acid, 9,11-epidioxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-, PGH(2) 
A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific… Expand
National Institutes of Health

Related topics

Related topics

15 relations
In BloodPTGS2 genePTGS2 protein, humanPTGS2 wt Allele
Expand

Narrower (1)

prostaglandin H2 9-cyclic ether

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Membrane prostaglandin E synthase-1: a novel therapeutic target.
Prostaglandin E(2) (PGE(2)) is the most abundant prostaglandin in the human body. It has a large number of biological actions… Expand
  • figure 1
  • figure 2
  • table 1
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase.
Prostaglandin (PG)E2 is a potent mediator of pain and inflammation, and high levels of this lipid mediator are observed in… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice
Arachidonic acid is metabolized to prostaglandin H2 (PGH2) by cyclooxygenase (COX). COX-2, the inducible COX isozyme, has a key… Expand
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Review
1999
Review
1999
The role of cyclooxygenases in inflammation, cancer, and development
The cyclooxygenase (COX) enzymes catalyze a key step in the conversion of arachidonate to PGH2, the immediate substrate for a… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells.
The formation of prostaglandins requires the catalytic activity of cyclooxygenase (COX) which converts arachidonic acid to the… Expand
Is this relevant?
Highly Cited
1994
Highly Cited
1994
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.
The three-dimensional structure of prostaglandin H2 synthase-1, an integral membrane protein, has been determined at 3.5 A… Expand
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.
Murine prostaglandin endoperoxide (PGH) synthase-1 and PGH synthase-2 expressed in cos-1 cells were found to be differentially… Expand
  • table I
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1983
Highly Cited
1983
Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay.
A highly sensitive fluorometric method for the quantitation of cholesterol, lipid, and other hydroperoxides at the picomole level… Expand
Is this relevant?
Highly Cited
1976
Highly Cited
1976
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that… Expand
Is this relevant?
Highly Cited
1976
Highly Cited
1976
Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation.
Fresh arterial tissue generates an unstable substance (prostablandin X) which relaxes vascular smooth muscle and potently… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE