FAQ

Prostaglandin H2

Known as: PGH2, Prosta-5,13-dien-1-oic acid, 9,11-epidioxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-, PGH(2) 
A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2017
0204019752017

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17 relations
In BloodPTGS2 genePTGS2 protein, humanPTGS2 wt Allele
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Narrower (2)

prostaglandin H2 9-cyclic etherprostaglandin H2 methyl ester

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Prostaglandin H2
physiological aspects
agonists
chemical synthesis
cyclooxygenase 2
standards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase.
Prostaglandin (PG)E2 is a potent mediator of pain and inflammation, and high levels of this lipid mediator are observed in… (More)
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Highly Cited
2002
Highly Cited
2002
High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion…
Loss of the modulatory role of the endothelium may be a critical initial factor in the development of diabetic vascular diseases… (More)
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Highly Cited
2001
Highly Cited
2001
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice
Arachidonic acid is metabolized to prostaglandin H2 (PGH2) by cyclooxygenase (COX). COX-2, the inducible COX isozyme, has a key… (More)
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Highly Cited
2001
Highly Cited
2001
Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever.
Fever is triggered by an elevation of prostaglandin E(2) (PGE(2)) in the brain. However, the mechanism of its elevation remains… (More)
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1997
1997
Endothelin and prostaglandin H2 enhance arteriolar myogenic tone in hypertension.
We hypothesized that endothelin in addition to prostaglandin (PG)H2 may also contribute to the enhanced myogenic tone of skeletal… (More)
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Highly Cited
1993
Highly Cited
1993
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.
Murine prostaglandin endoperoxide (PGH) synthase-1 and PGH synthase-2 expressed in cos-1 cells were found to be differentially… (More)
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Highly Cited
1983
Highly Cited
1983
Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay.
A highly sensitive fluorometric method for the quantitation of cholesterol, lipid, and other hydroperoxides at the picomole level… (More)
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Highly Cited
1981
Highly Cited
1981
Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations.
1 The actions of the prostaglandin H2 (PGH2) analogue, U-46619, have been compared with those of PGH2 on thromboxane A2 (TxA2) on… (More)
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Highly Cited
1976
Highly Cited
1976
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.
Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that… (More)
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Highly Cited
1976
Highly Cited
1976
Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation.
Fresh arterial tissue generates an unstable substance (prostablandin X) which relaxes vascular smooth muscle and potently… (More)
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