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Prostaglandin H2

Known as: PGH2, Prosta-5,13-dien-1-oic acid, 9,11-epidioxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-, PGH(2) 
A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific… Expand
National Institutes of Health

Related topics

Related topics

15 relations
In BloodPTGS2 genePTGS2 protein, humanPTGS2 wt Allele
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prostaglandin H2 9-cyclic ether

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2002
Review
2002
Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies.
Linoleic and alpha-linolenic acids, obtained from plant material in the diet are the precursors in tissues of two families with… Expand
Review
2001
Review
2001
Genetic and pharmacological analysis of prostanoid receptor function.
When tissues are exposed to diverse physiological and pathological stimuli, arachidonic acid is liberated from membrane… Expand
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Review
1999
Review
1999
The role of cyclooxygenases in inflammation, cancer, and development
The cyclooxygenase (COX) enzymes catalyze a key step in the conversion of arachidonate to PGH2, the immediate substrate for a… Expand
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Highly Cited
1994
Highly Cited
1994
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1
The three-dimensional structure of prostaglandin H2 synthase-1, an integral membrane protein, has been determined at 3.5… Expand
Highly Cited
1993
Highly Cited
1993
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.
Murine prostaglandin endoperoxide (PGH) synthase-1 and PGH synthase-2 expressed in cos-1 cells were found to be differentially… Expand
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Highly Cited
1983
Highly Cited
1983
Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay.
A highly sensitive fluorometric method for the quantitation of cholesterol, lipid, and other hydroperoxides at the picomole level… Expand
Highly Cited
1976
Highly Cited
1976
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that… Expand
Highly Cited
1976
Highly Cited
1976
Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.
Prostaglandin (PG) endoperoxides (PGG2 and PGH2) contract arterial smooth muscle and cause platelet aggregation. Microsomes from… Expand
Highly Cited
1976
Highly Cited
1976
Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation.
Fresh arterial tissue generates an unstable substance (prostablandin X) which relaxes vascular smooth muscle and potently… Expand
Highly Cited
1976
Highly Cited
1976
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation.
Microsomal fractions from arterial walls of pigs and rabbits and fundus of rat stomach generate from prostaglandin endoperoxides… Expand
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