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Prostaglandin H2
Known as:
PGH2
, Prosta-5,13-dien-1-oic acid, 9,11-epidioxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-
, PGH(2)
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A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific…
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National Institutes of Health
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Related topics
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15 relations
In Blood
PTGS2 gene
PTGS2 protein, human
PTGS2 wt Allele
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Narrower (1)
prostaglandin H2 9-cyclic ether
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target
B. Samuelsson
,
R. Morgenstern
,
P. Jakobsson
Pharmacological Reviews
2007
Corpus ID: 5870079
Prostaglandin E2 (PGE2) is the most abundant prostaglandin in the human body. It has a large number of biological actions that it…
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Review
2001
Review
2001
Genetic and pharmacological analysis of prostanoid receptor function.
S. Narumiya
,
G. FitzGerald
The Journal of clinical investigation
2001
Corpus ID: 12907274
When tissues are exposed to diverse physiological and pathological stimuli, arachidonic acid is liberated from membrane…
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Review
1999
Review
1999
The role of cyclooxygenases in inflammation, cancer, and development
Christopher S. Williams
,
M. Mann
,
R. DuBois
Oncogene
1999
Corpus ID: 40013802
The cyclooxygenase (COX) enzymes catalyze a key step in the conversion of arachidonate to PGH2, the immediate substrate for a…
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Highly Cited
1994
Highly Cited
1994
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1
D. Picot
,
P. Loll
,
R. Garavito
Nature
1994
Corpus ID: 4340064
The three-dimensional structure of prostaglandin H2 synthase-1, an integral membrane protein, has been determined at 3.5…
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Highly Cited
1993
Highly Cited
1993
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.
E. A. Meade
,
W. Smith
,
D. Dewitt
The Journal of biological chemistry
1993
Corpus ID: 24968392
Highly Cited
1983
Highly Cited
1983
Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay.
R. Cathcart
,
E. Schwiers
,
B. Ames
Analytical biochemistry
1983
Corpus ID: 29960395
Highly Cited
1976
Highly Cited
1976
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
S. Moncada
,
R. Gryglewski
,
S. Bunting
,
J. Vane
Nature
1976
Corpus ID: 4279030
Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that…
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Highly Cited
1976
Highly Cited
1976
Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.
R. Gryglewski
,
S. Bunting
,
S. Moncada
,
R. Flower
,
J. Vane
Prostaglandins
1976
Corpus ID: 36113753
Highly Cited
1976
Highly Cited
1976
Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation.
S. Bunting
,
R. Gryglewski
,
S. Moncada
,
J. Vane
Prostaglandins
1976
Corpus ID: 38123560
Highly Cited
1976
Highly Cited
1976
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation.
S. Moncada
,
R. Gryglewski
,
S. Bunting
,
J. Vane
Prostaglandins
1976
Corpus ID: 19885548
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