Prostaglandin H2

Known as: PGH2, Prosta-5,13-dien-1-oic acid, 9,11-epidioxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-, PGH(2) 
A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2017
0204019752017

Papers overview

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Highly Cited
2003
Highly Cited
2003
Prostaglandin (PG)E2 is a potent mediator of pain and inflammation, and high levels of this lipid mediator are observed in… (More)
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Highly Cited
2002
Highly Cited
2002
Loss of the modulatory role of the endothelium may be a critical initial factor in the development of diabetic vascular diseases… (More)
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Highly Cited
2001
Highly Cited
2001
Arachidonic acid is metabolized to prostaglandin H2 (PGH2) by cyclooxygenase (COX). COX-2, the inducible COX isozyme, has a key… (More)
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Highly Cited
2001
Highly Cited
2001
Fever is triggered by an elevation of prostaglandin E(2) (PGE(2)) in the brain. However, the mechanism of its elevation remains… (More)
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1997
1997
We hypothesized that endothelin in addition to prostaglandin (PG)H2 may also contribute to the enhanced myogenic tone of skeletal… (More)
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Highly Cited
1993
Highly Cited
1993
Murine prostaglandin endoperoxide (PGH) synthase-1 and PGH synthase-2 expressed in cos-1 cells were found to be differentially… (More)
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Highly Cited
1983
Highly Cited
1983
A highly sensitive fluorometric method for the quantitation of cholesterol, lipid, and other hydroperoxides at the picomole level… (More)
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Highly Cited
1981
Highly Cited
1981
1 The actions of the prostaglandin H2 (PGH2) analogue, U-46619, have been compared with those of PGH2 on thromboxane A2 (TxA2) on… (More)
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Highly Cited
1976
Highly Cited
1976
Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that… (More)
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Highly Cited
1976
Highly Cited
1976
Fresh arterial tissue generates an unstable substance (prostablandin X) which relaxes vascular smooth muscle and potently… (More)
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