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Prostaglandin H2

Known as: PGH2, Prosta-5,13-dien-1-oic acid, 9,11-epidioxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-, PGH(2) 
A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific… 
National Institutes of Health

Related topics

Related topics

15 relations
In BloodPTGS2 genePTGS2 protein, humanPTGS2 wt Allele

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prostaglandin H2 9-cyclic ether

Papers overview

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Highly Cited
2004
Highly Cited
2004
Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium.
OBJECTIVE Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the formation of PGE(2) from cyclooxygenase-derived PGH(2… 
Review
1994
Review
1994
Regulation of prostaglandin synthase-1 and prostaglandin synthase-2
It has been assumed that the rate-limiting step in the ligand-induced synthesis of prostaglandins is the release of arachidonic… 
Highly Cited
1985
Highly Cited
1985
Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme.
Highly Cited
1983
Highly Cited
1983
Ligand binding to thromboxane receptors on human platelets: correlation with biological activity
1 The preparation of enantiomerically pure [3H]‐15 (S) 9, 11‐epoxymethano PGH2 (a thromboxane A2‐like agonist) has enabled the… 
Highly Cited
1978
Highly Cited
1978
Renal actions of prostacyclin
A NEW and important member of the arachidonate–thromboxane–prostaglandin system, prostacyclin (PGI2), has recently been isolated1… 
Highly Cited
1977
Highly Cited
1977
Coronary tone modulation: formation and actions of prostaglandins, endoperoxides, and thromboxanes.
Exogenous prostaglandin (PGE2) contracts bovine and human coronary arteries but its precursor, arachidonic acid, relaxes them… 
Highly Cited
1977
Highly Cited
1977
Prostacyclin increases cyclic AMP levels and adenylate cyclase activity in platelets
PROSTACYCLIN (PGX) (ref. 1) is the name proposed for the metabolic product of a recently discovered enzymic transformation of the… 
Highly Cited
1977
Highly Cited
1977
Solubilization and resolution of thromboxane synthesizing system from microsomes of bovine blood platelets.
Highly Cited
1977
Highly Cited
1977
Prostaglandin endoperoxides and thromboxane A2 can induce platelet aggregation in the absence of secretion
PLATELET aggregation and secretion are widely studied not only because they are believed to reflect the major in vivo platelet… 
Highly Cited
1976
Highly Cited
1976
Formation and action of prostaglandin endoperoxides in the isolated human umbilical artery.
The effects on the isolated human umbilical artery (HUA) of the recently isolated endoperoxide intermediates in prostaglandin (PG… 
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