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Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils
TLDR
The hypothesis that adenosine 3′:5′‐cyclic monophosphate (cyclic AMP) is the second messenger mediating the inhibition of the neutrophil by prostaglandin (PG)E2.1 is tested. Expand
Platelet prostanoid receptors.
  • R. Armstrong
  • Chemistry, Medicine
  • Pharmacology & therapeutics
  • 1996
TLDR
There is strong evidence to support the existence of distinct thromboxane, prostacyclin, PGD2 and PGE2 receptors on the platelet plasma membrane, and each of these platelet prostanoid receptors is discussed in detail with respect to their receptor pharmacology, molecular biology and signal transduction. Expand
Comparison of the EP receptor subtypes mediating relaxation of the rabbit jugular and pig saphenous veins.
TLDR
Results suggest that the EP receptor present in the rabbit jugular vein (RJV), currently classified as an atypical EP2 receptor, is of the EP4 subtype, but this was not confirmed using theEP4 receptors antagonist AH 23,848B. Expand
Competitive antagonism at thromboxane receptors in human platelets
TLDR
The block of the aggregatory action of 11,9‐epoxymethano‐PGH2 by PTA2 appears to be mainly due to competition at the thromboxane receptor, and the validity of affinity constant determinations for receptor antagonists when aggregation is the biological response. Expand
The physiological role and pharmacological potential of nitric oxide in neutrophil activation.
  • R. Armstrong
  • Chemistry, Medicine
  • International immunopharmacology
  • 1 August 2001
TLDR
A better understanding of the inflammatory effects of NO on neutrophils is needed before the therapeutic potential of NO donors or inhibitors in inflammation can be realised. Expand
Heparin, platelet aggregation, neutrophils, and cardiopulmonary bypass.
TLDR
Fourteen patients undergoing routine aortocoronary bypass grafting and NSAID-free for over 7 days were studied before and after heparinisation, and at end-CPB, suggesting an indirect action by heparIn in vivo on macroaggregation, although hepar in had a small direct stimulatory action on microaggregation. Expand
Ligand binding to thromboxane receptors on human platelets: correlation with biological activity
1 The preparation of enantiomerically pure [3H]‐15 (S) 9, 11‐epoxymethano PGH2 (a thromboxane A2‐like agonist) has enabled the binding of ligands to the thromboxane receptor of the human platelet toExpand
Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors
TLDR
The main conclusion is that prostacyclin receptors on human, pig and horse platelets are similar in nature, but distinct from those on rabbit and rat platelets. Expand
Investigation of the role of nitric oxide and cyclic GMP in both the activation and inhibition of human neutrophils
TLDR
The finding that the guanylyl cyclase inhibitor LY 83583 completely inhibited chemotaxis and suppressed the maximal response suggests NO is a mediator of fMLP‐induced SAG, suggesting the paradox that NO both activates and inhibits human neutrophils is resolved. Expand
Aspects of the thromboxane receptor system.
TLDR
The aim of this review is to establish what is known about the thromboxane (TP) receptor, and to identify where future research is headed, particularly in relation to the potential role of epi prostaglandins. Expand
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