Skip to search formSkip to main contentSkip to account menu
Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils
TLDR
The hypothesis that adenosine 3′:5′‐cyclic monophosphate (cyclic AMP) is the second messenger mediating the inhibition of the neutrophil by prostaglandin (PG)E2.1 is tested.
View on Wiley
Investigation of the inhibitory effects of PGE2 and selective EP agonists on chemotaxis of human neutrophils
  • R. Armstrong
  • Biology, Medicine
    British journal of pharmacology
  • 1 December 1995
TLDR
The hypothesis that cyclic AMP is the second messenger involved in prostaglandin E2‐stimulated human neutrophils is tested, and the inhibitory effects of selective EP agonists and type IV phosphodiesterase (PDE) inhibitors, rolipram and Ro20‐1724 have been examined.
View on Wiley
Platelet prostanoid receptors.
  • R. Armstrong
  • Biology, Medicine
    Pharmacology & therapeutics
  • 1996
View on PubMed
The physiological role and pharmacological potential of nitric oxide in neutrophil activation.
  • R. Armstrong
  • Biology
    International immunopharmacology
  • 1 August 2001
View on PubMed
Comparison of the EP receptor subtypes mediating relaxation of the rabbit jugular and pig saphenous veins.
View on PubMed
Competitive antagonism at thromboxane receptors in human platelets
TLDR
The block of the aggregatory action of 11,9‐epoxymethano‐PGH2 by PTA2 appears to be mainly due to competition at the thromboxane receptor, and the validity of affinity constant determinations for receptor antagonists when aggregation is the biological response.
View on Wiley
Heparin, platelet aggregation, neutrophils, and cardiopulmonary bypass.
View on PubMed
Ligand binding to thromboxane receptors on human platelets: correlation with biological activity
1 The preparation of enantiomerically pure [3H]‐15 (S) 9, 11‐epoxymethano PGH2 (a thromboxane A2‐like agonist) has enabled the binding of ligands to the thromboxane receptor of the human platelet to…
View on Wiley
Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors
TLDR
The main conclusion is that prostacyclin receptors on human, pig and horse platelets are similar in nature, but distinct from those on rabbit and rat platelets.
View on Wiley
Investigation of the role of nitric oxide and cyclic GMP in both the activation and inhibition of human neutrophils
TLDR
The finding that the guanylyl cyclase inhibitor LY 83583 completely inhibited chemotaxis and suppressed the maximal response suggests NO is a mediator of fMLP‐induced SAG, suggesting the paradox that NO both activates and inhibits human neutrophils is resolved.
View on Wiley
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License