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Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
TLDR
Lactacystin appears to modify covalently the highly conserved amino-terminal threonine of the mammalian proteasome subunit X (also called MB1), a close homolog of the LMP7 proteasom subunit encoded by the major histocompatibility complex and may have a catalytic role. Expand
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta.
TLDR
The hypothesis that naturally occurring oxysterols are physiological ligand for LXRs is supported and a rational, structure-based approach can be used to design potent LXR ligands for pharmacologic use is shown. Expand
Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function.
TLDR
It is concluded that diets enriched with fish-oil-derived fatty acids may have antiinflammatory effects by inhibiting the 5-lipoxygenase pathway in neutrophils and monocytes and inhibition of the leukotriene B4-mediated functions of neutrophil. Expand
Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function
Abstract The effects of dietary fish-oil fatty acids on the function of the 5-lipoxygenase pathway of peripheral-blood polymorphonuclear leukocytes and monocytes were determined in seven normalExpand
Protection of hydroxyl groups as tert-butyldimethylsilyl derivatives
There is a need for development of chemical agents to protect hydroxyl groups. The agents developed must combine stability under varying circumstances with susceptibility to easy removal by aExpand
The Logic of Chemical Synthesis
Part 1 General approaches to the analysis of complex synthetic problems: the basis for retrosynthetic analysis transform-based strategies structure-based and topological strategies stereochemicalExpand
Computer-assisted design of complex organic syntheses.
Strategic applications of named reactions in organic synthesis: background and detailed mechanisms
TLDR
This main section includes 250 two-page entries about Named Organic Reactions, which lists the Named Reactions by Synthetic Type and by their Utility. Expand
Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis.
TLDR
The cardiovascular protective effects ascribed to dietary intake of fish lipid by certain populations may be due in part to the biological action of DCHA, including the inhibition of prostaglandin biosynthesis. Expand
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