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PTGS2 wt Allele

Known as: Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) wt Allele, COX2, hCOX-2 
Human PTGS2 wild type allele is located within 1q25.2-q25.3 and is approximately 9 kb in length. This allele, which encodes prostaglandin G/H… 
National Institutes of Health

Related topics

Related topics

12 relations
1q25.2-q25.3Homo sapiensOxidation-ReductionPPAR-alpha Gene Regulation Pathway

Broader (1)

PTGS2 gene

Papers overview

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Highly Cited
2001
Highly Cited
2001
Mechanism of acetaminophen inhibition of cyclooxygenase isoforms.
Acetaminophen has similar analgesic and antipyretic properties to nonsteroidal antiinflammatory drugs (NSAIDs), which act via… 
Highly Cited
2000
Highly Cited
2000
Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture.
We examined the effect on osteoclast formation of disrupting the prostaglandin G/H synthase genes PGHS-1 and-2. Prostaglandin E(2… 
Highly Cited
1999
Highly Cited
1999
Induction of prostaglandin G/H synthase-2 in a canine model of spontaneous prostatic adenocarcinoma.
BACKGROUND Prostate cancer is the most frequently occurring cancer in men in the United States, with an estimated 179 300 new… 
Highly Cited
1997
Highly Cited
1997
Nitric Oxide Trapping of the Tyrosyl Radical of Prostaglandin H Synthase-2 Leads to Tyrosine Iminoxyl Radical and Nitrotyrosine Formation*
The determination of protein nitrotyrosine content has become a frequently used technique for the detection of oxidative tissue… 
Highly Cited
1997
Highly Cited
1997
Regulation of human monocyte matrix metalloproteinases by SPARC
SPARC (secreted protein, acidic and rich in cysteine), also called osteonectin or BM‐40, is a collagen‐binding glycoprotein… 
Highly Cited
1996
Highly Cited
1996
Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect.
Evidence from epidemiological studies, clinical trials, and animal experiments indicates that inhibitors of prostaglandin… 
1996
1996
Selective inhibition of cyclooxygenase-1 and -2 using intact insect cell assays.
Highly Cited
1995
Highly Cited
1995
Differential expression of prostaglandin-H synthase isoenzymes in normal and activated keratinocytes in vivo and in vitro.
Normal mouse epidermis constitutively expresses prostaglandin-H synthase 1 (PGHS-1) but no PGHS-2. Acute inflammation and… 
Highly Cited
1994
Highly Cited
1994
Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae.
A second prostaglandin G/H synthase (PGHS-2), encoded by a gene separate from that for the original PGHS (PGHS-1), has recently… 
Highly Cited
1993
Highly Cited
1993
Structural determination and promoter analysis of the chicken mitogen-inducible prostaglandin G/H synthase gene and genetic mapping of the murine homolog.
We have previously reported the isolation and characterization of a new form (PGHS-2) of prostaglandin G/H synthase (PGHS… 
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