• Publications
  • Influence
Cyclooxygenases: structural, cellular, and molecular biology.
The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin synthesis. PGHS-1 and 2 are ofExpand
  • 2,575
  • 150
  • PDF
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2*
Prostaglandin endoperoxide H synthases (PGHSs) catalyze the conversion of arachidonic acid and O2 to PGH2, the committed step in prostanoid biosynthesis (Fig. 1) (1). Before 1991, only one PGHS hadExpand
  • 1,920
  • 74
  • PDF
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.
Murine prostaglandin endoperoxide (PGH) synthase-1 and PGH synthase-2 expressed in cos-1 cells were found to be differentially sensitive to inhibition by common nonsteroidal anti-inflammatory drugsExpand
  • 1,195
  • 50
  • PDF
Prostaglandin endoperoxide H synthases-1 and -2.
Publisher Summary The chapter compares and contrasts the structural and kinetic properties of prostaglandin endoperoxide H synthase-1 (PGHS-1) and -2. It also discusses the description of theExpand
  • 730
  • 30
Prostaglandin and thromboxane biosynthesis.
We describe the enzymological regulation of the formation of prostaglandin (PG) D2, PGE2, PGF2 alpha, 9 alpha, 11 beta-PGF2, PGI2 (prostacyclin), and thromboxane (Tx) A2 from arachidonic acid. WeExpand
  • 446
  • 19
Prostaglandin endoperoxide synthase: regulation of enzyme expression.
  • D. Dewitt
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 8 May 1991
  • 636
  • 18
Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.
We developed an in vitro expression system for accurate kinetic analyses of the inhibition of the human prostaglandin H synthase isozymes (hPGHS-1 and -2) by nonsteroidal anti-inflammatory drugsExpand
  • 469
  • 16
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.
  • D. Dewitt, W. Smith
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 March 1988
Prostaglandin G/H synthase (8,11,14-icosatrienoate, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.1) catalyzes the first step in the formation of prostaglandins and thromboxanes, the conversion ofExpand
  • 585
  • 15
Cox-2-selective inhibitors: the new super aspirins.
  • D. Dewitt
  • Medicine
  • Molecular pharmacology
  • 1 April 1999
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen are commonly used for the occasional headache or fever or to reduce soreness and inflammation resulting from work orExpand
  • 239
  • 14
  • PDF
The 19-amino Acid Cassette of Cyclooxygenase-2 Mediates Entry of the Protein into the Endoplasmic Reticulum-associated Degradation System*
Cyclooxygenase (COX) isoforms catalyze the committed step in prostaglandin biosynthesis. The primary structures of COX-1 and COX-2 are very similar except that COX-2 has a 19-amino acid (19-AA)Expand
  • 102
  • 14