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Cyclooxygenases: structural, cellular, and molecular biology.
The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin synthesis. PGHS-1 and 2 are of… Expand
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2*
- W. Smith, R. Garavito, D. Dewitt
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 27 December 1996
Prostaglandin endoperoxide H synthases (PGHSs) catalyze the conversion of arachidonic acid and O2 to PGH2, the committed step in prostanoid biosynthesis (Fig. 1) (1). Before 1991, only one PGHS had… Expand
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.
Murine prostaglandin endoperoxide (PGH) synthase-1 and PGH synthase-2 expressed in cos-1 cells were found to be differentially sensitive to inhibition by common nonsteroidal anti-inflammatory drugs… Expand
Prostaglandin endoperoxide H synthases-1 and -2.
Publisher Summary The chapter compares and contrasts the structural and kinetic properties of prostaglandin endoperoxide H synthase-1 (PGHS-1) and -2. It also discusses the description of the… Expand
Prostaglandin and thromboxane biosynthesis.
We describe the enzymological regulation of the formation of prostaglandin (PG) D2, PGE2, PGF2 alpha, 9 alpha, 11 beta-PGF2, PGI2 (prostacyclin), and thromboxane (Tx) A2 from arachidonic acid. We… Expand
Prostaglandin endoperoxide synthase: regulation of enzyme expression.
- D. Dewitt
- Biology, Medicine
- Biochimica et biophysica acta
- 8 May 1991
Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.
- O. Laneuville, D. Breuer, D. Dewitt, T. Hla, C. Funk, W. Smith
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 November 1994
We developed an in vitro expression system for accurate kinetic analyses of the inhibition of the human prostaglandin H synthase isozymes (hPGHS-1 and -2) by nonsteroidal anti-inflammatory drugs… Expand
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.
Prostaglandin G/H synthase (8,11,14-icosatrienoate, hydrogen-donor:oxygen oxidoreductase, EC 220.127.116.11) catalyzes the first step in the formation of prostaglandins and thromboxanes, the conversion of… Expand
Cox-2-selective inhibitors: the new super aspirins.
- D. Dewitt
- Molecular pharmacology
- 1 April 1999
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen are commonly used for the occasional headache or fever or to reduce soreness and inflammation resulting from work or… Expand
The 19-amino Acid Cassette of Cyclooxygenase-2 Mediates Entry of the Protein into the Endoplasmic Reticulum-associated Degradation System*
- U. Mbonye, Masayuki Wada, C. Rieke, H. Tang, D. Dewitt, W. Smith
- Medicine, Biology
- Journal of Biological Chemistry
- 24 November 2006
Cyclooxygenase (COX) isoforms catalyze the committed step in prostaglandin biosynthesis. The primary structures of COX-1 and COX-2 are very similar except that COX-2 has a 19-amino acid (19-AA)… Expand