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Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target.
The enzyme activity is glutathione-dependent, and the protein expression is induced by the proinflammatory cytokine IL-1beta, which makes PGE synthase a potential novel target for drug development. Expand
Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target
Differences in the kinetics of the expression of the two enzymes suggest distinct regulatory mechanisms for their expression of prostaglandin E2, indicating that mPGES-1 is a potential target for the development of therapeutic agents for treatment of several diseases. Expand
Leukotrienes and lipoxins: structures, biosynthesis, and biological effects.
The multiple interaction of lipoxygenases generates compounds that can regulate specific cellular responses of importance in inflammation and immunity. Expand
Ribonuclease activity and RNA binding of recombinant human Dicer
Cl cloning and expression of the 218 kDa human Dicer are reported, and characterization of its ribonuclease activity and dsRNA‐binding properties are described, suggesting that ionic interactions are involved in ds RNA cleavage. Expand
Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.
Evidence is presented that the more unstable and major component of rabbit aorta contracting substance (RCS) formed in platelets and guinea pig lung is also thromboxane A2. Expand
Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides
The microsomal fraction of horse and human platelets contains an enzyme which converts prostaglandin cyclic endoperoxides (PGG2 or PGH2) to a substance which is much more potent in contracting stripsExpand
5-Lipoxygenase: regulation of expression and enzyme activity.
Knowing the biochemistry of this enzyme has potential implications for the treatment of various diseases and the understanding of the regulatory mechanisms underlying the expression and control of 5-LO activity is expanded. Expand
Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation.
Platelet aggregation induced by thrombin was accompanied by release of material reducible by stannous chloride into prostaglandin F(2alpha), thus indicating the involvement of endogenous prostaglandsin endoperoxides in platelet aggregation. Expand
Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187.
The data demonstrate that, in addition to causing release of endogenous substrate, the ionophore also activated the enzymatic system involved in the further transformations of arachidonic acid. Expand