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Prostaglandin-Endoperoxide Synthase

Known as: Endoperoxide Synthetase, Prostaglandin, Synthase, Prostaglandin H, Synthetase, Prostaglandin H2 
Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor… 
National Institutes of Health

Related topics

Related topics

19 relations
Enzyme GeneIn BloodOxidation-ReductionOxidoreductase Gene

Broader (2)

Multienzyme ComplexesOxygenases

Narrower (4)

PTGS1 protein, humancyclooxygenase 1cyclooxygenase 2cyclooxygenase-3

Papers overview

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Highly Cited
1983
Highly Cited
1983
Bimodal distribution of the prostaglandin I2 synthase antigen in smooth muscle cells.
Vascular and nonvascular smooth muscles in 12 different organs from the gastrointestinal, respiratory, and urogenital tracts of… 
Highly Cited
1983
Highly Cited
1983
The oxidation of 2-aminofluorene by prostaglandin endoperoxide synthetase. Comparison with other peroxidases.
We have examined the prostaglandin endoperoxide synthetase-dependent metabolism of the arylamine carcinogen 2-aminofluorene (2-AF… 
Highly Cited
1982
Highly Cited
1982
Inhibiton of prostaglandin synthesis by human amniotic fluid: acute reduction in inhibitory activity of amniotic fluid obtained during labor.
Human amniotic fluid contains an inhibitor of prostaglandin synthesis. The activity of the inhibitor was measured in amniotic… 
Highly Cited
1982
Highly Cited
1982
Cooxidation of the clinical reagent 3,5,3'5'-tetramethylbenzidine by prostaglandin synthase.
Prostaglandin synthase catalyzes the oxidation of arachidonic acid to prostaglandin H2 via a hydroperoxide intermediate… 
Highly Cited
1980
Highly Cited
1980
Benzidine binding to nucleic acids mediated by the peroxidative activity of prostaglandin endoperoxide synthetase.
The cooxidative metabolism of the urinary bladder carcinogen benzidine was examined using renal inner medullary microsomes. The… 
Highly Cited
1975
Highly Cited
1975
Dopamine Induced Relaxation of Isolated Canine Renal, Mesenteric, and Femoral Arteries Contracted with Prostaglandin F2α
The purpose of this investigation was to develop a system for studying the effects of dopamine on isolated blood vessels. Canine… 
Highly Cited
1972
Highly Cited
1972
Effects of prostaglandin E2 on rat skin: inhibition of sterol ester biosynthesis and clearing of scaly lesions in essential fatty acid deficiency
: Severe scaly lesions in the skin, especially in the feet and tail, of the rat were induced by feeding a diet deficient in… 
Highly Cited
1971
Highly Cited
1971
Mechanism of prostaglandin biosynthesis. I. Characterization and assay of bovine prostaglandin synthetase.
Highly Cited
1971
Highly Cited
1971
On the metabolism of prostaglandin F 2 in female subjects. II. Structures of six metabolites.
In vitro studies of PG (prostaglandin) metabolism have shown that they can be transformed by oxidation of the allylic alcohol… 
Highly Cited
1965
Highly Cited
1965
SYNTHESIS OF TRITIUM-LABELED PROSTAGLANDIN E-2 AND STUDIES ON ITS METABOLISM IN GUINEA PIG LUNG. 37. PROSTAGLANDINS AND RELATED FACTORS.