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Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability
Targeting this molecule in inflammatory disease conditions offers a new strategy for prevention of endothelial barrier dysfunction caused by misdirected leukocyte activation, and suggests a fundamental role of neutrophil-derived HBP in the vascular response to neutrophils trafficking in inflammation.
Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.
It is suggested that leukotrienes, formed in several blood-borne and tissue-bound cells, may mediate important microcirculatory adjustments to noxious stimuli.
Leukotrienes are potent constrictors of human bronchi
The remarkable contractile activity of both LTC4 and LTD4 on isolated human bronchi is reported, which further emphasizes the possibility that leukotrienes are potent mediators of ronchoconstriction in man.
Chemoattractant-induced firm adhesion of leukocytes to vascular endothelium in vivo is critically dependent on initial leukocyte rolling.
The results demonstrate quantitatively a close relationship between the extent of leukocyte rolling and the magnitude of the subsequent firm adhesion response, and, that an initial rolling interaction is a precondition for firmAdhesion to occur at physiological blood flow rates in vivo.
Characteristics of histamine‐induced leukocyte rolling in the undisturbed microcirculation of the rat mesentery
Initial leukocyte recruitment after mast cell activation in the rat mesentery is critically dependent on histamine release, and the histamine‐induced PMNL rolling was not dependent on nitric oxide synthesis, but was sensitive to glucocorticoid treatment.
Integrin alpha(2)beta(1) (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue.
Cell adhesion molecules are critically involved in the multistep process of leukocyte recruitment in inflammation. The specific receptors used by polymorphonuclear leukocytes (PMN) for locomotion in
Identification and biological activity of novel ω‐oxidized metabolites of leukotriene B4 from human leukocytes
The formation of a novel dihydroxy-acid, 5S,12S-dihydroxy-6-trans,8-cis,lOtrans,l4-c is-eicosatetraenoic acid (SS,12SDHETE), in preparations of human leukocytes is reported and further conversion of this trihydroxy acid to a dicarboxylic acid (20-COOH-LTB4).
β1 Integrins Are Critically Involved in Neutrophil Locomotion in Extravascular Tissue In Vivo
It is demonstrated that cell surface expression of β1 integrins, although limited on blood PMNs, is induced in extravasated PMNs and that members of the β1 Integrin family other than α4β1 and α5β1 are critically involved in the chemokinetic movement of PMNs in rat extravascular tissue in vivo.