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cyclooxygenase 2

Known as: PTGS2, COX-2 Prostaglandin Synthase, PGHS-2 
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is… Expand
National Institutes of Health

Papers overview

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Review
2006
Review
2006
Cyclooxygenease-2 (COX-2) is the key enzyme regulating the production of prostaglandins, central mediators of inflammation. The… Expand
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Highly Cited
2003
Highly Cited
2003
Parkinson's disease (PD) is a neurodegenerative disorder of uncertain pathogenesis characterized by the loss of the nigrostriatal… Expand
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Highly Cited
2002
Highly Cited
2002
Cyclooxygenase-2 (Cox-2) expression can induce mammary tumorigenesis in transgenic mice, and selective Cox-2 inhibitors are both… Expand
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Highly Cited
2001
Highly Cited
2001
Results from our previous studies demonstrated that activation of Toll-like receptor 4 (Tlr4), the lipopolysaccharide (LPS… Expand
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Highly Cited
2001
Highly Cited
2001
The cyclooxygenase (COX)-2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in adenocarcinomas and… Expand
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Highly Cited
2000
Highly Cited
2000
Here we report the molecular identification of membrane-bound glutathione (GSH)-dependent prostaglandin (PG) E2 synthase (mPGES… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Numerous studies have demonstrated that the levels of prostaglandins are greater in various cancers, including breast… Expand
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Highly Cited
1997
Highly Cited
1997
Recent epidemiologic studies have shown a 40-50% reduction in mortality from colorectal cancer in individuals who take… Expand
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Highly Cited
1994
Highly Cited
1994
Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used for the treatment of inflammatory diseases, but significant side… Expand
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Highly Cited
1992
Highly Cited
1992
Cyclooxygenase (Cox), also known as prostaglandin (PG) H synthase (EC 1.14.99.1), catalyzes the rate-limiting step in the… Expand
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