cyclooxygenase 2

Known as: PTGS2, COX-2 Prostaglandin Synthase, PGHS-2 
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2017
05010019882017

Papers overview

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Highly Cited
2004
Highly Cited
2004
Overexpression of human cyclooxygenase 2 (COX-2) in the mammary glands of transgenic mice induces tissue-specific tumorigenic… (More)
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Highly Cited
2004
Highly Cited
2004
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopamine-containing neurons, but the molecular… (More)
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Highly Cited
2002
Highly Cited
2002
Cyclooxygenase-2 (Cox-2) expression can induce mammary tumorigenesis in transgenic mice, and selective Cox-2 inhibitors are both… (More)
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Highly Cited
2002
Highly Cited
2002
Cyclooxygenase-2 (COX-2) is expressed within neovascular structures that support many human cancers. Inhibition of COX-2 by… (More)
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Highly Cited
2001
Highly Cited
2001
Cyclooxygenase (COX)-2 is an inducible enzyme involved in production of prostaglandins in inflammatory processes. There is now… (More)
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Highly Cited
2000
Highly Cited
2000
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been observed to reduce the relative risk of breast cancer. This prompted our… (More)
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Highly Cited
2000
Highly Cited
2000
The up-regulation of cyclooxygenase 2 (COX-2) expression is a frequent occurrence in a variety of different tumors. In this study… (More)
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Highly Cited
1998
Highly Cited
1998
Cyclooxygenase (COX)-2 expression was immunohistochemically examined in 59 human lung cancers as well as in normal and… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND & AIMS The role of two forms of cyclooxygenase (COX-1 and COX-2) in gastric mucosal lesions is not well understood… (More)
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Highly Cited
1994
Highly Cited
1994
We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the… (More)
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