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cyclooxygenase 2

Known as: PTGS2, COX-2 Prostaglandin Synthase, PGHS-2 
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is… 
National Institutes of Health

Related topics

Related topics

15 relations
In BloodMT-CO2 genePTGS2 wt AlleleProcess of secretion

Narrower (3)

PTGS2 protein, humanPtgs2 protein, mousePtgs2 protein, rat

Broader (1)

Prostaglandin-Endoperoxide Synthase

Papers overview

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Highly Cited
2003
Highly Cited
2003
Expression of cyclooxygenase-2 in renal cell carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival.
PURPOSE Cyclooxygenase (COX)-2 plays an important role in tumor cell proliferation, resistance to apoptosis, angiogenesis, and… 
Highly Cited
2002
Highly Cited
2002
Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells.
The inducible cyclooxygenase-2 (COX-2) gene regulates prostaglandin biosynthesis,is up-regulated in colorectal cancers, and can… 
Highly Cited
2001
Highly Cited
2001
Transcriptional silencing of Cyclooxygenase-2 by hyper-methylation of the 5' CpG island in human gastric carcinoma cells.
It has been well established that overexpression of Cyclooxygenase-2 (Cox-2) in epithelial cells inhibits apoptosis and increases… 
Highly Cited
2000
Highly Cited
2000
Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4.
Recently, a microsomal protein with 38% sequence identity to microsomal glutathione S-transferase 1 was shown to constitute an… 
Highly Cited
2000
Highly Cited
2000
Prostaglandin H synthase 2 expression in airway cells from patients with asthma and chronic obstructive pulmonary disease.
Products of the prostaglandin H synthase (PGHS) metabolic pathway are thought to play a role in the pathogenesis of asthma. We… 
Highly Cited
2000
Highly Cited
2000
Traumatic injury induces differential expression of cell death genes in organotypic brain slice cultures determined by complementary DNA array hybridization
Highly Cited
1999
Highly Cited
1999
Different functional aspects of the group II subfamily (Types IIA and V) and type X secretory phospholipase A(2)s in regulating arachidonic acid release and prostaglandin generation. Implications of…
We have recently reported that members of the heparin-binding group II subfamily of secretory PLA(2)s (sPLA(2)s) (types IIA and V… 
Highly Cited
1998
Highly Cited
1998
Human Intestinal Epithelial Cells Respond toCryptosporidium parvum Infection with Increased Prostaglandin H Synthase 2 Expression and Prostaglandin E2and F2α Production
ABSTRACT Cryptosporidium parvum is an important cause of diarrhea in humans and several animal species. Prostaglandins play a… 
Highly Cited
1995
Highly Cited
1995
Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers.
Highly Cited
1994
Highly Cited
1994
Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae.
A second prostaglandin G/H synthase (PGHS-2), encoded by a gene separate from that for the original PGHS (PGHS-1), has recently… 
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