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Sonic Hedgehog Induces Capillary Morphogenesis by Endothelial Cells through Phosphoinositide 3-Kinase*
Sonic hedgehog (Shh) acts as a morphogen in many cell types. Recent studies have shown that hedgehog signaling is involved in vascular development as well as postnatal angiogenesis. However, theExpand
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Clinicopathological correlation of polypoidal choroidal vasculopathy revealed by ultrastructural study
Aims: To describe the clinical and histopathological findings in a patient with polypoidal choroidal vasculopathy. Methods: A 76 year old Japanese man had a discrete, orange-red lesion of 1 discExpand
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The selective tyrosine kinase inhibitor, STI571, inhibits growth of anaplastic thyroid cancer cells.
To establish a molecular targeting therapy for anaplastic thyroid carcinomas, we studied the effect of the specific tyrosine kinase inhibitor, STI571, on anaplastic thyroid cancer cell lines highlyExpand
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Induction of macrophage VEGF in response to oxidized LDL and VEGF accumulation in human atherosclerotic lesions.
The interaction between macrophages and oxidatively modified low density lipoprotein (Ox-LDL) appears to play a central role in the development of atherosclerosis, not only through foam cellExpand
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Small-molecule inhibitors of the c-Fes protein-tyrosine kinase.
The c-Fes protein-tyrosine kinase modulates cellular signaling pathways governing differentiation, the innate immune response, and vasculogenesis. Here, we report the identification of types I and IIExpand
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Deficiency of Gelatinase A Suppresses Smooth Muscle Cell Invasion and Development of Experimental Intimal Hyperplasia
Background—Although it has been demonstrated that matrix metalloproteinases (MMPs) play an important role in the arterial remodeling in atherosclerosis and restenosis, it is not clear which MMP isExpand
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Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation
We have examined fibroblast growth factor (FGF) receptor-1 mediated signal transduction in differentiation of endothelial cells (EC). The activated FGFR-1 couples to Ras through two adaptor proteins,Expand
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Phosphatidylinositol 3′-Kinase-independent p70 S6 Kinase Activation by Fibroblast Growth Factor Receptor-1 Is Important for Proliferation but Not Differentiation of Endothelial Cells*
p70s6k has a role in cell cycle progression in response to specific extracellular stimuli. The signal transduction pathway leading to activation of p70s6k by fibroblast growth factor receptor-1Expand
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Lymphangiogenesis and Angiogenesis in Bladder Cancer: Prognostic Implications and Regulation by Vascular Endothelial Growth Factors-A, -C, and -D
Purpose: Lymph vessel density (LVD) and microvessel density (MVD) correlate with the malignant potential of tumors and patient survival. Vascular endothelial growth factors (VEGF)-A, VEGF-C, andExpand
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Effects of vitamin D(3)-binding protein-derived macrophage activating factor (GcMAF) on angiogenesis.
BACKGROUND The vitamin D(3)-binding protein (Gc protein)-derived macrophage activating factor (GcMAF) activates tumoricidal macrophages against a variety of cancers indiscriminately. We investigatedExpand
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