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Analysis of Chicken Mucosal Immune Response to Eimeria tenella and Eimeria maxima Infection by Quantitative Reverse Transcription-PCR
TLDR
In the chicken macrophage cell line HD-11, CC chemokines, MGF, IL-1β, and iNOS were inducible by IFN-γ, suggesting that macrophages may be one of the cell populations involved in the upregulation of these cytokines observed in vivo during infection with Eimeria. Expand
Role of Cryptosporidium parvum as a pathogen in neonatal diarrhoea complex in suckling and dairy calves in France
TLDR
Cryptosporidium prevalence is higher in suckling than in dairy calves and C. parvum constitutes actually in both cases the major aetiological agent of neonatal diarrhoea, and the pressure of the other pathogenic agents remains relatively stable. Expand
Cryptosporidium parvum-Specific Mucosal Immune Response in C57BL/6 Neonatal and Gamma Interferon-Deficient Mice: Role of Tumor Necrosis Factor Alpha in Protection
TLDR
The results of the present study indicate that the resolution of infection is dependent on the expression of Th1-type cytokines in the mucosa of C57BL/6 mice and that TNF-α may participate in the control of parasite development. Expand
Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines
TLDR
The results demonstrate that upregulated expression and secretion of IL-8 and GROalpha after C. parvum infection of intestinal epithelial cells first occurred 16 to 24 h after infection and increased over the ensuing 1 to 2 days, suggesting that C-X-C chemokines produced by those cells contribute to the mucosal inflammatory cell infiltrate in the underlying intestinal mucosa. Expand
The effect of halofuginone lactate on experimental Cryptosporidium parvum infections in calves
TLDR
The results clearly demonstrated the efficacy of halofuginone lactate in reducing the severity of clinical cryptosporidiosis and this efficacy was dose-dependent. Expand
Role of Gamma Interferon in Chemokine Expression in the Ileum of Mice and in a Murine Intestinal Epithelial Cell Line after Cryptosporidium parvum Infection
TLDR
The altered response of chemokines responsible for the recruitment of macrophages and T cells in GKO mice suggests that these two populations may be critical in the development of a protective immune response. Expand
Human Intestinal Epithelial Cells Respond toCryptosporidium parvum Infection with Increased Prostaglandin H Synthase 2 Expression and Prostaglandin E2and F2α Production
TLDR
Prostaglandins play a central role in regulating intestinal fluid secretion in animal models of cryptosporidiosis, but their cellular sources and mechanisms of induction are unclear and C. parvuminfection directly activates prostaglandsin H synthase 2 expression and prostaglandin E2 and F2α production in human intestinal epithelial cells. Expand
Genotyping human and bovine isolates of Cryptosporidium parvum by polymerase chain reaction-restriction fragment length polymorphism analysis of a repetitive DNA sequence.
TLDR
The PCR-RFLP assay described here is a sensitive tool to distinguish C. parvum isolates and Typing of 23 isolates showed that 10/10 calf isolates had the same profile, while 2 patterns were observed among human isolates: 7/13 displayed the calf profile, and 6/13 presented another pattern. Expand
Cryptosporidium parvum in calves: kinetics and immunoblot analysis of specific serum and local antibody responses (immunoglobulin A [IgA], IgG, and IgM) after natural and experimental infections
TLDR
Challenge reinfection of naturally infected calves at day 112 was not followed by clinical signs or oocyst output or by a secondary antibody response, and reinfections were established 5, 7, and 14 weeks after the primary contact. Expand
Protection of kids against Cryptosporidium parvum infection after immunization of dams with CP15-DNA.
TLDR
It is reported that nasal immunization of pregnant goats with CP15-DNA led to a transfer of immunity to offspring conferring protection against C. parvum infection, which should reduce the economic losses due to cryptosporidiosis in ruminants, specially in small ruminant (calves, lambs, kids). Expand
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