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Eicosanoids and cancer
Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that have been implicated in various pathological processes, such as inflammation and cancer. This Review… Expand
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
The JAK-STAT signaling pathway has been implicated in mediating biological responses induced by many cytokines. However, cytokines that promote distinct cellular responses often activate identical… Expand
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas.
- Clovis Eberhart, R. Coffey, A. Radhika, F. Giardiello, S. Ferrenbach, R. Dubois
- 1 October 1994
BACKGROUND/AIMS Several clinical, epidemiological, and animal studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) may alter the incidence of colorectal cancer. A likely target for… Expand
Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.
- H. Sheng, J. Shao, J. Morrow, R. Beauchamp, R. Dubois
- Biology, Medicine
- Cancer research
- 15 January 1998
Previously, we have shown that forced expression of prostaglandin endoperoxide synthase-2 [also called cyclooxygenase (COX) 2] leads to inhibition of programmed cell death in intestinal epithelial… Expand
Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
Prostaglandin endoperoxide synthase 2, also referred to as cyclooxygenase 2 (COX-2), is a key enzyme in the conversion of arachidonic acid to prostaglandins and other eicosanoids. Rat intestinal… Expand
Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential.
- M. Tsujii, S. Kawano, R. Dubois
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 April 1997
Recent epidemiologic studies have shown a 40-50% reduction in mortality from colorectal cancer in individuals who take nonsteroidal antiinflammatory drugs on a regular basis compared with those not… Expand
Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells*
- H. Sheng, J. Shao, M. Washington, R. Dubois
- Medicine, Biology
- The Journal of Biological Chemistry
- 25 May 2001
Chronic use of nonsteroidal anti-inflammatory drugs results in a significant reduction of risk and mortality from colorectal cancer in humans. All of the mechanism(s) by which nonsteroidal… Expand
The role of COX-2 in intestinal inflammation and colorectal cancer
Colorectal cancer (CRC) is a heterogeneous disease, including at least three major forms: hereditary, sporadic and colitis-associated CRC. A large body of evidence indicates that genetic mutations,… Expand
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta.
We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate-limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization.… Expand