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cyclooxygenase 1

Known as: COX-1 Prostaglandin Synthase, Cyclooxygenase-1, Synthase, COX-1 Prostaglandin 
A constitutively-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes.
National Institutes of Health

Related topics

Related topics

16 relations
In BloodPTGS1 genePTGS1 wt AllelePTGS2 protein, human

Narrower (3)

PTGS1 protein, humanProstaglandin-Endoperoxide Synthase 1 Deficiency, Plateletcyclooxygenase-3

Broader (1)

Prostaglandin-Endoperoxide Synthase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Response to Letter Regarding Article, “Association of Cyclooxygenase-1–Dependent and –Independent Platelet Function Assays With Adverse Clinical Outcomes in Aspirin-Treated Patients Presenting for…
Our conclusion that “poor clinical outcomes of aspirin-treated patients is due in part to incomplete cyclooxygenase-1 (COX-1… 
Highly Cited
2009
Highly Cited
2009
Response to aspirin in healthy individuals
Summary Variable biological effect of aspirin is suggested to be related to pharmacological resistance. The incidence of this so… 
2008
2008
Letter by Klein regarding article, "Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study".
To the Editor: I read with interest the recently published report on the Aspirin-Induced Platelet Effect (ASPECT) study.1 A few… 
Highly Cited
2001
Highly Cited
2001
Ischemic preconditioning, the most effective gastroprotective intervention: involvement of prostaglandins, nitric oxide, adenosine and sensory nerves.
Highly Cited
2001
Highly Cited
2001
Both cyclooxygenase-1 and cyclooxygenase-2 mediate osteoblast response to titanium surface roughness.
Previous studies suggest that the enhanced expression of the osteoblastic phenotype exhibited by MG63 osteoblast-like cells on… 
Highly Cited
2000
Highly Cited
2000
Analytical and pharmacological investigation of Ocotea bullata (black stinkwood) bark and leaves.
2000
2000
Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2 activity and azoxymethane-induced aberrant crypt foci development in rats.
Review
1999
Review
1999
Inhibition by dietary menhaden oil of cyclooxygenase-1 and -2 in N-nitrosomethylurea-induced rat mammary tumors.
Studies in laboratory animals and epidemiological surveys suggest a relationship between the type and amount of dietary fat and… 
Highly Cited
1998
Highly Cited
1998
The effect of dietary n-3 and n-6 polyunsaturated fatty acids on the expression of cyclooxygenase 1 and 2 and levels of p21ras in rat mammary glands.
Dietary n-6 polyunsaturated fatty acids (PUFAs) promote rat mammary cancer while n-3 PUFAs are inhibitory. The purpose of this… 
Highly Cited
1994
Highly Cited
1994
Characterization of the tyrosyl radicals in ovine prostaglandin H synthase-1 by isotope replacement and site-directed mutagenesis.
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