cyclooxygenase 1

Known as: COX-1 Prostaglandin Synthase, Cyclooxygenase-1, Synthase, COX-1 Prostaglandin 
A constitutively-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes.
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
Two cyclooxygenase isozymes, COX-1 and -2, are known to catalyze the rate-limiting step of prostaglandin synthesis and are the… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND & AIMS Selective cyclooxygenase (COX)-2 inhibitors produce less gastric damage than conventional nonsteroidal anti… (More)
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Highly Cited
2000
Highly Cited
2000
Here we report the molecular identification of cytosolic glutathione (GSH)-dependent prostaglandin (PG) E(2) synthase (cPGES), a… (More)
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Review
1998
Review
1998
Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to prostaglandins was first identified over… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Numerous studies have demonstrated that the levels of prostaglandins are greater in various cancers, including breast… (More)
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Highly Cited
1998
Highly Cited
1998
The enzymes cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin… (More)
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Highly Cited
1998
Highly Cited
1998
PURPOSE Both isoforms of cyclo-oxygenase, COX-1 and COX-2, are inhibited to varying degrees by all of the available nonsteroidal… (More)
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Highly Cited
1995
Highly Cited
1995
Several studies indicate that nonsteroidal anti-inflammatory drugs including indomethacin, aspirin, sulindac, and piroxicam… (More)
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Highly Cited
1994
Highly Cited
1994
High levels of immunoreactive cyclooxygenase (Cox; prostaglandin H synthase) are present in synovia from patients with rheumatoid… (More)
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Highly Cited
1993
Highly Cited
1993
The rate-limiting step in the formation of prostanoids is the conversion of arachidonic acid to prostaglandin H2 by… (More)
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