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PTGS1 wt Allele

Known as: COX1, PGHS-1, COX3 
Human PTGS1 wild type allele is located within 9q32-q33.3 and is approximately 25 kb in length. This allele, which encodes prostaglandin G/H synthase… 
National Institutes of Health

Related topics

Related topics

12 relations
9q32-q33.3Angiogenic ProcessHomeostasisHomo sapiens

Broader (1)

PTGS1 gene

Papers overview

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Highly Cited
2004
Highly Cited
2004
Coordination of Meiotic Recombination, Pairing, and Synapsis by PHS1
Pairing, synapsis, and recombination are prerequisites for accurate chromosome segregation in meiosis. The phs1 gene in maize is… 
Highly Cited
1999
Highly Cited
1999
Allergic lung responses are increased in prostaglandin H synthase-deficient mice.
To investigate the function of prostaglandin H synthase-1 and synthase-2 (PGHS-1 and PGHS-2) in the normal lung and in allergic… 
Highly Cited
1997
Highly Cited
1997
Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs.
We have evaluated the selectivity in vitro of various conventional nonsteroidal anti-inflammatory drugs (NSAIDs) and new anti… 
Highly Cited
1996
Highly Cited
1996
Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-Iiodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site (*)
Previous studies of the crystal structure of the ovine prostaglandin endoperoxide H synthase-1 (PGHS-1)/S-flurbiprofen complex… 
Highly Cited
1996
Highly Cited
1996
Involvement of Arginine 120, Glutamate 524, and Tyrosine 355 in the Binding of Arachidonate and 2-Phenylpropionic Acid Inhibitors to the Cyclooxygenase Active Site of Ovine Prostaglandin Endoperoxide…
Examination of the crystal structure of the ovine prostaglandin endoperoxide synthase-1 (PGHS-1)/S-flurbiprofen complex (Picot, D… 
Highly Cited
1995
Highly Cited
1995
Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and −2
Human prostaglandin-endoperoxide H synthase-1 and −2 (hPGHS-1 and hPGHS-2) were expressed by transient transfection of COS-1… 
Highly Cited
1995
Highly Cited
1995
Prostaglandin endoperoxide-H synthase-1 and -2 messenger ribonucleic acid levels in human amnion with spontaneous labor onset.
Increased prostaglandin (PG) production within the uterine compartment has a pivotal role in the processes leading to labor onset… 
Highly Cited
1995
Highly Cited
1995
Effects of the novel anti‐inflammatory compounds, N‐[2‐(cyclohexyloxy)‐4‐nitrophenyl] methanesulphonamide (NS‐398) and 5‐methanesulphonamido‐6‐(2, 4‐difluorothiophenyl)‐1‐indanone (L‐745, 337), on…
1 We have evaluated the selectivity of ketoprofen and two novel nonsteroidal anti‐inflammatory drugs, N‐[2‐(cyclohexyloxy)‐4… 
Highly Cited
1994
Highly Cited
1994
Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes.
We and others have previously demonstrated that human alveolar macrophages produce more PGE2 in response to lipopolysaccharide… 
Highly Cited
1993
Highly Cited
1993
Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells.
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