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PTGS1 gene

Known as: PTGS1, PROSTAGLANDIN G/H SYNTHASE 1, COX1 
This gene plays a role in the regulation of angiogenesis in endothelial cells.
National Institutes of Health

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Related topics

10 relations
Angiogenic ProcessHomeostasisOxidation-ReductionPTGS1 protein, human

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PTGS1 wt Allele

Papers overview

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Highly Cited
2005
Highly Cited
2005
Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition.
Platelet activation is a hallmark of severe preeclampsia, and platelet PGH synthase 1-derived (PGHS1-derived) thromboxane A(2… 
Highly Cited
2000
Highly Cited
2000
Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture.
We examined the effect on osteoclast formation of disrupting the prostaglandin G/H synthase genes PGHS-1 and-2. Prostaglandin E(2… 
Highly Cited
1997
Highly Cited
1997
Conversion of Prostaglandin G/H Synthase-1 into an Enzyme Sensitive to PGHS-2-selective Inhibitors by a Double His513 → Arg and Ile523 → Val Mutation*
Modeling of the active site of prostaglandin G/H synthase-2 (PGHS-2) onto PGHS-1 utilizing the known crystal structure of PGHS-1… 
Highly Cited
1997
Highly Cited
1997
Differential Allosteric Regulation of Prostaglandin H Synthase 1 and 2 by Arachidonic Acid*
Prostaglandins are synthesized by prostaglandin H synthase (PGHS) 1 and 2. PGHS2 is regulated through inducible expression. We… 
Highly Cited
1996
Highly Cited
1996
Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts.
BACKGROUND & AIMS In the gastrointestinal tract, prostaglandins are implicated as important mediators of normal physiological… 
Highly Cited
1996
Highly Cited
1996
Involvement of Arginine 120, Glutamate 524, and Tyrosine 355 in the Binding of Arachidonate and 2-Phenylpropionic Acid Inhibitors to the Cyclooxygenase Active Site of Ovine Prostaglandin Endoperoxide…
Examination of the crystal structure of the ovine prostaglandin endoperoxide synthase-1 (PGHS-1)/S-flurbiprofen complex (Picot, D… 
Highly Cited
1995
Highly Cited
1995
c-Kit Ligand Mediates Increased Expression of Cytosolic Phospholipase A, Prostaglandin Endoperoxide Synthase-1, and Hematopoietic Prostaglandin D Synthase and Increased IgE-dependent Prostaglandin D…
We have examined the cytokine regulation of IgEdependent prostaglandin (PG) D2 generation in mouse mast cells by assessing the… 
Highly Cited
1994
Highly Cited
1994
Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes.
We and others have previously demonstrated that human alveolar macrophages produce more PGE2 in response to lipopolysaccharide… 
Highly Cited
1993
Highly Cited
1993
Structural determination and promoter analysis of the chicken mitogen-inducible prostaglandin G/H synthase gene and genetic mapping of the murine homolog.
We have previously reported the isolation and characterization of a new form (PGHS-2) of prostaglandin G/H synthase (PGHS… 
Highly Cited
1993
Highly Cited
1993
Prostaglandin G/H synthase isoenzyme 2 expression in fibroblasts: regulation by dexamethasone, mitogens, and oncogenes.
Mitogens increase prostaglandin synthesis in fibroblasts. In the present studies, transcriptional activation of the prostaglandin… 
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