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Prostaglandins and leukotrienes: advances in eicosanoid biology.
- C. Funk
- 30 November 2001
Important insights into the mechanisms of inflammatory responses, pain, and fever have been gleaned from the current understanding of eicosanoid biology. Expand
Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase
Findings reveal a physiological role of 12/15-lipoxygenase in the generation of endogenous ligands for PPAR-γ, and suggest a paradigm for the regulation of nuclear receptor function by cytokines. Expand
Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase.
Findings reveal a physiological role of 12/15-lipoxygenase in the generation of endogenous ligands for PPAR-gamma, and suggest a paradigm for the regulation of nuclear receptor function by cytokines. Expand
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease.
The Leukotriene Pathway and a Common Unstable Intermediate 5869 is discovered and a Role for the Aminopeptidase Activity during Resolution of Inflammation is identified. Expand
Mice Deficient in Cellular Glutathione Peroxidase Develop Normally and Show No Increased Sensitivity to Hyperoxia*
- Y. Ho, J. Magnenat, +4 authors C. Funk
- Biology, Medicine
- The Journal of Biological Chemistry
- 27 June 1997
The results suggest that the contribution of GSHPx-1 to the cellular antioxidant mechanism under normal animal development and physiological conditions and to the pulmonary defense against hyperoxic insult is very limited. Expand
Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.
- O. Laneuville, D. Breuer, D. Dewitt, T. Hla, C. Funk, W. Smith
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 November 1994
An in vitro expression system for accurate kinetic analyses of the inhibition of the human prostaglandin H synthase isozymes by nonsteroidal anti-inflammatory drugs (NSAIDs) indicates that neither measurements of affinities of NSAIDs for hPGHS-2 conducted in vitro with 10 microM arachidonate nor measurements of time-dependent inhibition of hPG HS-2 always predict whether a compound has anti- inflammatory activity in vivo. Expand
The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm
It is shown that 5-LO-positive macrophages localize to the adventitia of diseased mouse and human arteries in areas of neoangiogenesis and that these cells constitute a main component of aortic aneurysms induced by an atherogenic diet containing cholate in mice deficient in apolipoprotein E. Expand
Salt–sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor
Data demonstrate that the EP2 receptor mediates arterial dilatation, salt–sensitive hypertension, and also plays an essential part in female fertility, as demonstrated in mice created with targeted disruption of this gene. Expand
Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function.
- Yan Cheng, Miao Wang, Ying Yu, J. Lawson, C. Funk, G. FitzGerald
- Biology, Medicine
- The Journal of clinical investigation
- 1 May 2006
The results suggest that inhibitors of mPGES-1 may retain their antiinflammatory efficacy by depressing PGE(2), while avoiding the adverse cardiovascular consequences associated with PGHS-2-mediated PGI(2) suppression. Expand
Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.
- C. Funk, L. Furci, +6 authors K. Metters
- Biology, Medicine
- The Journal of biological chemistry
- 15 December 1993
The human EP1 receptor subtype, a functional cDNA clone coding for the human prostaglandin E receptor EP1 subtype which is functionally coupled to an increase in intracellular Ca2+. Expand