Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.
- T. Kawamori, C. Rao, K. Seibert, B. Reddy
- Medicine, BiologyCancer Research
- 1 February 1998
Evidence is provided, for the first time, that a specific COX-2 inhibitor, celecoxib, possesses strong chemopreventive activity against colon carcinogenesis.
Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer.
- T. Kawamori, R. Lubet, B. Reddy
- Biology, MedicineCancer Research
- 1 February 1999
Administration of curcumin to the rats during the initiation and postinitiation stages and throughout the promotion/progression stage increased apoptosis in the colon tumors as compared to colon tumors in the groups receiving AOM and the control diet.
Modulation of experimental colon tumorigenesis by types and amounts of dietary fatty acids.
- C. Rao, Y. Hirose, C. Indranie, B. Reddy
- MedicineCancer Research
- 3 March 2001
Results indicate that the modulation of eicosanoid production via the influence on COX activity and the suppression of apoptosis may play a key role in HFML diet-induced colon tumorigenesis.
Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.
- C. Rao, A. Rivenson, B. Simi, B. Reddy
- Biology, MedicineCancer Research
- 15 January 1995
Investigation of the chemopreventive action of dietary curcumin on azoxymethane-induced colon carcinogenesis and also the modulating effect of this agent on the colonic mucosal and tumor phospholipase A2, phospholIPase C gamma 1, lipoxygenase, and cyclo oxygengenase activities in male F344 rats indicates that dietary administration ofCurcumin significantly inhibited incidence of colon adenocarcinomas.
Enhancement of experimental colon cancer by genistein.
- C. Rao, C. X. Wang, B. Reddy
- Biology, MedicineCancer Research
- 1 September 1997
The results of this investigation emphasize that the biological effects of genistein may be organ specific, inhibiting cancer development in some sites yet showing no effect or an enhancing effect on the tumorigenesis at other sites, such as the colon.
Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate.
- F. Chung, C. Conaway, C. Rao, B. Reddy
- Biology, MedicineCarcinogenesis
- 1 December 2000
Findings provide important laboratory evidence for a potential role of SFN and PEITC in the protection against colon cancer.
Chemopreventive effect of squalene on colon cancer.
- C. Rao, H. Newmark, B. Reddy
- BiologyCarcinogenesis
- 1 February 1998
The finding that Squalene significantly suppresses colonic ACF formation and crypt multiplicity strengthens the hypothesis that squalene possesses chemopreventive activity against colon carcinogenesis.
Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor.
- C. Rao, T. Kawamori, R. Hamid, B. Reddy
- Biology, MedicineCarcinogenesis
- 1 April 1999
Observations suggest that iNOS may play a key regulatory role in colon carcinogenesis and developingiNOS-specific inhibitors may provide a selective and safe chemopreventive strategy for colon cancer treatment.
Docosahexaenoic acid regulated genes and transcription factors inducing apoptosis in human colon cancer cells.
- B. Narayanan, N. Narayanan, B. Reddy
- BiologyInternational Journal of Oncology
- 1 December 2001
The results indicated that DHA inhibits the growth of CaCo-2 cells and induces apoptosis, and support the conclusion that a genomewide expression profiling of human colon cancer precursor genes and transcription factors provides a set of novel regulatory mechanism to determine the chemopreventive efficacy of DHA and thus to prevent the inflammation and neoplasia.
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