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Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica.
TLDR
Clinical studies aimed at investigating the sedative, analgesic, antidepressive, antimicrobial, antiviral and immunomodulatory effects that have been demonstrated experimentally are still lacking.
Matrix as a modulator of hepatic fibrogenesis.
TLDR
Current ECM-related antifibrotic strategies are based on the identification and in vivo application ofECM-derived biomodulatory peptides, peptide sequences, or their nonpeptidic mimetics that open the opportunity of oral application and an extended biological half-life.
Herbal products for liver diseases: A therapeutic challenge for the new millennium
TLDR
Herbal extracts derived from licorice root, Phyllanthus amarus, milk thistle, Picrorhiza kurroa, and sho-saiko-to can serve as primary compounds for the development of specific hepatotropic drugs.
Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome.
TLDR
The improved insulin sensitivity after 2 nights of treatment may reflect a decreasing sympathetic activity, indicating that sleep apnea is an independent risk factor for increased insulin resistance.
Thrombocytopenia in patients in the medical intensive care unit: Bleeding prevalence, transfusion requirements, and outcome*
TLDR
Thrombocytopenic patients have a higher prevalence of bleeding and greater transfusion requirements, and a drop in platelet counts of ≥30%, but not throm bocytopenia per se, is independently associated with intensive care unit death.
Health-related quality of life of patients with multiple organ dysfunction: Individual changes and comparison with normative population
TLDR
This study has shown that preadmission health-related quality of life of medical, noncoronary patients was substantially reduced compared with a matched general population, demonstrating the need to take prehospitalization health- related quality ofLife into account when examining the outcomes of intensive care unit survivors.
Readmissions and adverse drug reactions in internal medicine: the economic impact
TLDR
This study focuses on the relationship between adverse drug reactions (ADRs) and readmittance to a department of internal medicine and the number of patients readmitted to hospital within 6 months of discharge.
Hepatitis C and liver fibrosis
TLDR
Knowledge of profibrogenic polymorphisms in genes that are relevant during fibrogenesis will make it possible to identify those patients who are most likely to progress and who need antiviral or antifibrotic therapies most urgently, and an effective and individualised treatment of liver fibrosis is anticipated.
The Effect of Continuous Positive Airway Pressure Treatment on Insulin Sensitivity in Patients with Obstructive Sleep Apnoea Syndrome and Type 2 Diabetes
TLDR
The results indicate that OSA itself is an independent risk factor for insulin resistance, and this effect may be explained by the elevated sympathetic activity in OSA.
The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells.
TLDR
TSA inhibits hepatoma cell growth in vitro, which is otherwise particularly resistant to chemotherapy, and its anti-proliferative activity is paralleled by a comparable rate of apoptosis.
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