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Prostaglandin E2

Known as: PGE2, 5-Heptenoic Acid, 7-(3-Hydroxy-2-(3-Hydroxy-1-Octenyl)-5-Oxocyclopentyl)- (8CI), Prosta-5,13-Dien-1-Oic Acid, 11,15-Dihydroxy-9-Oxo-, (5Z,11alpha,13E,15S)- 
A prostaglandin with 2 double bonds that is generated by the action of prostaglandin E synthases on prostaglandin H2. Prostaglandin E2 is a mediator… 
National Institutes of Health

Papers overview

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Review
2012
Review
2012
PGE2, an essential homeostatic factor, is also a key mediator of immunopathology in chronic infections and cancer. The impact of… 
Highly Cited
2009
Highly Cited
2009
Various studies analyzed the inhibitory effect exerted by mesenchymal stem cells (MSCs) on cells of the innate or acquired… 
Highly Cited
2007
Highly Cited
2007
Haematopoietic stem cell (HSC) homeostasis is tightly controlled by growth factors, signalling molecules and transcription… 
Highly Cited
2005
Highly Cited
2005
Naturally occurring CD4+CD25+ regulatory T cells (T reg) are pivotal in suppressing immune responses and maintaining tolerance… 
Highly Cited
2002
Highly Cited
2002
Dendritic cells (DCs) are potent antigen-presenting cells that are able to initiate and modulate immune responses and are hence… 
Highly Cited
2001
Highly Cited
2001
Chronic use of nonsteroidal anti-inflammatory drugs results in a significant reduction of risk and mortality from colorectal… 
Highly Cited
2000
Highly Cited
2000
Here we report the molecular identification of membrane-bound glutathione (GSH)-dependent prostaglandin (PG) E2 synthase (mPGES… 
Highly Cited
2000
Highly Cited
2000
Here we report the molecular identification of cytosolic glutathione (GSH)-dependent prostaglandin (PG) E2 synthase (cPGES), a… 
Highly Cited
1998
Highly Cited
1998
Previously, we have shown that forced expression of prostaglandin endoperoxide synthase-2 [also called cyclooxygenase (COX) 2… 
Highly Cited
1991
Highly Cited
1991
PGE2 is known to inhibit IL-2 and IFN-gamma production from Th cells and is widely viewed as a general immunosuppressant. However…