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Prostaglandin E2

Known as: PGE2, 5-Heptenoic Acid, 7-(3-Hydroxy-2-(3-Hydroxy-1-Octenyl)-5-Oxocyclopentyl)- (8CI), Prosta-5,13-Dien-1-Oic Acid, 11,15-Dihydroxy-9-Oxo-, (5Z,11alpha,13E,15S)- 
A prostaglandin with 2 double bonds that is generated by the action of prostaglandin E synthases on prostaglandin H2. Prostaglandin E2 is a mediator… 
National Institutes of Health

Related topics

Related topics

4 relations
DinoprostoneProstaglandin E2 MeasurementProstaglandin E2:MCnc:24H:Urine:QnProstaglandin E2:MRat:24H:Urine:Qn

Papers overview

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Highly Cited
2009
Highly Cited
2009
MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2.
Various studies analyzed the inhibitory effect exerted by mesenchymal stem cells (MSCs) on cells of the innate or acquired… 
Highly Cited
2003
Highly Cited
2003
MIF Signal Transduction Initiated by Binding to CD74
Macrophage migration inhibitory factor (MIF) accounts for one of the first cytokine activities to have been described, and it has… 
Highly Cited
2001
Highly Cited
2001
Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells*
Chronic use of nonsteroidal anti-inflammatory drugs results in a significant reduction of risk and mortality from colorectal… 
Highly Cited
1997
Highly Cited
1997
Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells.
C19 steroids are converted to estrogens by aromatase P450 (P450arom). Aromatase expression in humans is regulated by use of… 
Highly Cited
1997
Highly Cited
1997
IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells.
We studied to what extent the presence of an inflammatory mediator PGE2, during the development of dendritic cells (DC) affects… 
Highly Cited
1993
Highly Cited
1993
Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes.
PGE2 is a well known immunomodulator that has multiple effects on the immune system. We demonstrate that PGE2 selectively and… 
Highly Cited
1991
Highly Cited
1991
Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.
PGE2 is known to inhibit IL-2 and IFN-gamma production from Th cells and is widely viewed as a general immunosuppressant. However… 
Highly Cited
1990
Highly Cited
1990
The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.
Highly Cited
1986
Highly Cited
1986
Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1
Recombinant human tumor necrosis factor (rTNF alpha) injected intravenously into rabbits produces a rapid-onset, monophasic fever… 
Highly Cited
1970
Highly Cited
1970
Prostaglandins: stimulation of bone resorption in tissue culture.
Prostaglandins (PG’s) stimulated resorption of fetal rat bone in 48–96 hr tissue culture. The effects of several PG’s were… 
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