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Prostaglandin E2

Known as: PGE2, 5-Heptenoic Acid, 7-(3-Hydroxy-2-(3-Hydroxy-1-Octenyl)-5-Oxocyclopentyl)- (8CI), Prosta-5,13-Dien-1-Oic Acid, 11,15-Dihydroxy-9-Oxo-, (5Z,11alpha,13E,15S)- 
A prostaglandin with 2 double bonds that is generated by the action of prostaglandin E synthases on prostaglandin H2. Prostaglandin E2 is a mediator… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
  • P. Kalinski
  • The Journal of Immunology
  • 2012
  • Corpus ID: 54616563
PGE2, an essential homeostatic factor, is also a key mediator of immunopathology in chronic infections and cancer. The impact of… 
Highly Cited
2007
Highly Cited
2007
Haematopoietic stem cell (HSC) homeostasis is tightly controlled by growth factors, signalling molecules and transcription… 
Highly Cited
2005
Highly Cited
2005
Naturally occurring CD4+CD25+ regulatory T cells (T reg) are pivotal in suppressing immune responses and maintaining tolerance… 
Highly Cited
2001
Highly Cited
2001
Chronic use of nonsteroidal anti-inflammatory drugs results in a significant reduction of risk and mortality from colorectal… 
Highly Cited
2000
Highly Cited
2000
Here we report the molecular identification of membrane-bound glutathione (GSH)-dependent prostaglandin (PG) E2 synthase (mPGES… 
Highly Cited
2000
Highly Cited
2000
Here we report the molecular identification of cytosolic glutathione (GSH)-dependent prostaglandin (PG) E2 synthase (cPGES), a… 
Highly Cited
1998
Highly Cited
1998
Previously, we have shown that forced expression of prostaglandin endoperoxide synthase-2 [also called cyclooxygenase (COX) 2… 
Highly Cited
1993
Highly Cited
1993
PGE2 is a well known immunomodulator that has multiple effects on the immune system. We demonstrate that PGE2 selectively and… 
Highly Cited
1991
Highly Cited
1991
PGE2 is known to inhibit IL-2 and IFN-gamma production from Th cells and is widely viewed as a general immunosuppressant. However… 
Highly Cited
1983
Highly Cited
1983
To clarify the mechanisms underlying the loss of body protein during fever and sepsis, we incubated rat muscles with highly…