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Prostaglandin E2
Known as:
PGE2
, 5-Heptenoic Acid, 7-(3-Hydroxy-2-(3-Hydroxy-1-Octenyl)-5-Oxocyclopentyl)- (8CI)
, Prosta-5,13-Dien-1-Oic Acid, 11,15-Dihydroxy-9-Oxo-, (5Z,11alpha,13E,15S)-
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A prostaglandin with 2 double bonds that is generated by the action of prostaglandin E synthases on prostaglandin H2. Prostaglandin E2 is a mediator…
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National Institutes of Health
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Related topics
Related topics
4 relations
Dinoprostone
Prostaglandin E2 Measurement
Prostaglandin E2:MCnc:24H:Urine:Qn
Prostaglandin E2:MRat:24H:Urine:Qn
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Regulation of Immune Responses by Prostaglandin E2
P. Kalinski
Journal of Immunology
2012
Corpus ID: 54616563
PGE2, an essential homeostatic factor, is also a key mediator of immunopathology in chronic infections and cancer. The impact of…
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Highly Cited
2009
Highly Cited
2009
MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2.
G. Spaggiari
,
H. Abdelrazik
,
F. Becchetti
,
L. Moretta
Blood
2009
Corpus ID: 206878089
Various studies analyzed the inhibitory effect exerted by mesenchymal stem cells (MSCs) on cells of the innate or acquired…
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Highly Cited
2007
Highly Cited
2007
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
T. North
,
W. Goessling
,
+11 authors
L. Zon
Nature
2007
Corpus ID: 4432236
Haematopoietic stem cell (HSC) homeostasis is tightly controlled by growth factors, signalling molecules and transcription…
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Highly Cited
2005
Highly Cited
2005
Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells1
Felicita E. Baratelli
,
Ying Q Lin
,
+7 authors
S. Dubinett
Journal of Immunology
2005
Corpus ID: 27309440
Naturally occurring CD4+CD25+ regulatory T cells (T reg) are pivotal in suppressing immune responses and maintaining tolerance…
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Highly Cited
2002
Highly Cited
2002
Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells.
E. Scandella
,
Y. Men
,
S. Gillessen
,
R. Förster
,
M. Groettrup
Blood
2002
Corpus ID: 14464198
Dendritic cells (DCs) are potent antigen-presenting cells that are able to initiate and modulate immune responses and are hence…
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Highly Cited
2001
Highly Cited
2001
Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells*
H. Sheng
,
J. Shao
,
M. Washington
,
R. Dubois
Journal of Biological Chemistry
2001
Corpus ID: 38761621
Chronic use of nonsteroidal anti-inflammatory drugs results in a significant reduction of risk and mortality from colorectal…
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Highly Cited
2000
Highly Cited
2000
Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2*
M. Murakami
,
H. Naraba
,
+8 authors
I. Kudo
Journal of Biological Chemistry
2000
Corpus ID: 19699825
Here we report the molecular identification of membrane-bound glutathione (GSH)-dependent prostaglandin (PG) E2 synthase (mPGES…
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Highly Cited
2000
Highly Cited
2000
Molecular Identification of Cytosolic Prostaglandin E2 Synthase That Is Functionally Coupled with Cyclooxygenase-1 in Immediate Prostaglandin E2Biosynthesis*
T. Tanioka
,
Yoshihito Nakatani
,
Natsuki Semmyo
,
M. Murakami
,
I. Kudo
Journal of Biological Chemistry
2000
Corpus ID: 13484811
Here we report the molecular identification of cytosolic glutathione (GSH)-dependent prostaglandin (PG) E2 synthase (cPGES), a…
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Highly Cited
1998
Highly Cited
1998
Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.
H. Sheng
,
J. Shao
,
J. Morrow
,
R. Beauchamp
,
R. Dubois
Cancer Research
1998
Corpus ID: 5957290
Previously, we have shown that forced expression of prostaglandin endoperoxide synthase-2 [also called cyclooxygenase (COX) 2…
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Highly Cited
1991
Highly Cited
1991
Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.
M. Betz
,
B. Fox
Journal of Immunology
1991
Corpus ID: 22374670
PGE2 is known to inhibit IL-2 and IFN-gamma production from Th cells and is widely viewed as a general immunosuppressant. However…
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