MIF Signal Transduction Initiated by Binding to CD74

@article{Leng2003MIFST,
  title={MIF Signal Transduction Initiated by Binding to CD74},
  author={Lin Leng and Christine N Metz and Yan Fang and Jing Xu and Seamas C. Donnelly and John A. Baugh and Thomas M. Delohery and Yibang Chen and Robert A. Mitchell and Richard J. Bucala},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={197},
  pages={1467 - 1476}
}
Macrophage migration inhibitory factor (MIF) accounts for one of the first cytokine activities to have been described, and it has emerged recently to be an important regulator of innate and adaptive immunity. MIF is an upstream activator of monocytes/macrophages, and it is centrally involved in the pathogenesis of septic shock, arthritis, and other inflammatory conditions. The protein is encoded by a unique but highly conserved gene, and X-ray crystallography studies have shown MIF to define a… Expand
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TLDR
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Link between macrophage migration inhibitory factor and cellular redox regulation.
TLDR
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TLDR
Novel molecular information is provided about the structural elements that govern the interaction between MIF and CXCR4 that identify similarities with classical chemokine-receptor interactions but also provide evidence for a partial allosteric agonist compared with CXCL12 that is possible due to the two binding sites of CX CR4. Expand
Evolving complexity of MIF signaling.
TLDR
D-dopachrome tautomerase (D-DT or MIF-2) was recognized to be a structural and functional homolog of MIF, which could exert overlapping effects, raising further the complexity of canonical MIF signaling pathways. Expand
Ribosomal Protein S19 Interacts with Macrophage Migration Inhibitory Factor and Attenuates Its Pro-inflammatory Function*
TLDR
It is proposed that the ribosomal protein S19 (RPS19) acts as an extracellular negative regulator of MIF, which is implicated in the pathogenesis of inflammatory disorders such as infection, sepsis, and autoimmune disease. Expand
Both host and parasite MIF molecules bind to chicken macrophages via CD74 surface receptor.
TLDR
It is reported that chicken CD74 (ChCD74), a type II transmembrane protein, functions as a macrophage surface receptor that binds to MIF molecules, and Eimeria MIF (EMIF) bound to chicken macrophages via ChCD74p41 as a surface receptor. Expand
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It is reported that MIF plays an important regulatory role in the activation of T cells induced by mitogenic or antigenic stimuli and assigned a previously unsuspected but critical role for MIF in antigen-specific immune responses. Expand
Sustained Mitogen-activated Protein Kinase (MAPK) and Cytoplasmic Phospholipase A2 Activation by Macrophage Migration Inhibitory Factor (MIF)
TLDR
It is indicated that the sustained activation of p44/p42 MAP kinase and subsequent arachidonate release by cytoplasmic phospholipase A2 are important features of the immunoregulatory and intracellular signaling events initiated by MIF and provide the first insight into the mechanisms that underlie the pro-proliferative and inflammatory properties of this mediator. Expand
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Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1
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It is concluded that MIF may act broadly to negatively regulate Jab1-controlled pathways and that the MIF–Jab1 interaction may provide a molecular basis for key activities of MIF. Expand
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TLDR
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TLDR
A new biological function is reported for MIF, as an inhibitor of monocyte chemoattractant protein 1- (MCP-1-) induced chemotaxis of human peripheral blood monocytes, and it is found that MIF inhibition ofChemotaxis does not occur at the level of the CC chemokine receptor for M CP-1, CCR2, since MIF does not alter the binding of (125)I-MCP -1 to monocytes. Expand
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TLDR
It is reported that the iminoquinone metabolite of acetaminophen, N-acetyl-p-benzoquinone imine (NAPQI), inhibits both the isomerase and the biological activities of MIF, pointing to a powerful approach for the design of small molecule inhibitors of Mif based on interaction with its catalytic site. Expand
CHARACTERIZATION OF A LYMPHOCYTE FACTOR WHICH ALTERS MACROPHAGE FUNCTIONS
TLDR
The data suggests that the activating factor is the same as MIF and that, in vitro, macrophages respond to this substance with migration inhibition before they become sensitive to its activating influence. Expand
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